Objective: Children with epilepsy are at significant risk for a variety of psychosocial difficulties, including neurocognitive deficits, social skills problems, behavioral challenges, and psychiatric disorders. These factors are often intertwined, each contributing to difficulty in other domains, making it difficult to prioritize treatment options. We will describe the specific epilepsy variables that may contribute to increased risk of developmental challenges across domains. The prevalence rates of anxiety disorders in pediatric epilepsy range from 5–49%, depression rates range from 13–30%, and rates of ADHD vary between 12–33%. We plan to present prevalence rates of common psychiatric comorbidities, and discuss the complex psychosocial profile of children with epilepsy. Specifically, we will address the impact of neurocognitive difficulties on social and behavioral presentations in pediatric epilepsy, and how they impact the delivery of nonphramacological interventions. Finally, we will discuss ways in which to effectively identify psychosocial difficulties in epilepsy. Learning Objectives: 1. Identify the prevalence rates in children and adolescents with epilepsy, and describe the specific epilepsy variables that may increase the risk of developmental challenges delays in intelligence, learning, and language. 2. Understand the potential implications of neurobehavioral comorbidities on cognitive development in children with epilepsy. 3. Understand the impact of learning and social problems in epilepsy that may impact anxiety, underlie depression, and impact the delivery of nonpharmacological treatment modalities. 4. Identify screening tools and methods to help identify psychosocial comorbidities associated with epilepsy.