Objective: To examine the relationship between neuropsychological test performance in individuals with a higher versus lower percentage of American Indian heritage. Method: Our sample included 55 older (age 50 to 88) participants from the Choctaw Nation in Oklahoma who were cognitively intact. They were divided into higher (>50%) and lower (<50%) American Indian (AI) heritage percentage groups based upon self-report of Choctaw ancestry. The high AI percentage group consisted of 24 females and six males [M age = 63.43 (SD = 9.59), M education =12.73 (SD = 1.98), M MMSE = 28.57 (SD = 1.10)]. The low AI percentage group included 15 females and nine males [M age = 61.84 (SD = 6.97), M education = 13.36 (SD = 2.34), M MMSE = 27.85 (SD = 2.10)]. Independent t-tests were performed to compare test scores between higher and lower AI percentage groups. Results: No significant differences were seen on any of the neuropsychological measures between higher and lower AI percentage groups. Follow-up independent t-tests on the upper and lower quartiles of AI percentage groups yielded similar results. Conclusion: Self-reported percentage of American Indian heritage among rural dwelling Choctaw participants does not seem to influence neuropsychological test performance.