Objective: The purpose of this study was to determine if previously reported relationships between reading ability and personality test performance was accounted for by underlying relationships between each of those variables and verbal comprehension ability. Method: Participants were recruited from a university-based outpatient neuropsychology clinic (n = 169; age = 32.68, SD = 12.01; education = 13.74, SD = 2.08; 69% female; 63% Caucasian). Participants with a diagnosis of Specific Learning Disorder were excluded from the analysis. Reading ability was assessed using the Nelson-Denny Reading Test (NDRT). Self-reported personality was assessed using the Minnesota Multiphasic Personality Inventory-2 (MMPI-2) and the Millon Clinical Multiaxial Inventory-III (MCMI-III). Verbal comprehension ability was assessed using the WAIS-IV. Partial and zero order correlations were calculated. Results: All findings are significant at .05. After controlling for verbal comprehension ability on the relationship between reading comprehension ability and self-report personality test performance, significant partial correlations (all negative) were found between reading comprehension and both personality tests (MMPI-2 Clinical Scales F, 2, 3, 6, and 0; MCMI-III scales 4, 5, T, and CC). Conclusion: Results suggested that individuals with poor reading comprehension skills are at an elevated risk of being identified as depressed, psychotic, social isolated, and dependence on drugs by the MMPI-2, and to a lessor extent, the MCMI-III. The interpretive value of these scales is questionable for poor readers. Assessment of reading ability is warranted in any evaluation where these personality tests are used. Performance on subtests from the WAIS-IV should not be relied on in isolation to make this determination.