Objective: The purpose of our study was to examine pure memory and executive function (EF) contributions to medication management in healthy, young adults using the Medication Management Ability Assessment (MMAA) and computerized tasks believed to tap exclusively into memory and EF domains. We predicted that the EF computerized task would significantly contribute to MMAA performance compared to the memory computerized task. Method: Fifteen healthy, young adults (2 men; mean age = 21.46, SD = 3.23) participated. First, participants completed MMAA, a task that provides a realistic elucidation of medication management. Participants are given instructions for taking fake medications and then are asked to inform the researcher how and when they will take pills. Then, participants performed the Reversal Task (RT), an adaption of previous EF experiments shown to depend on the orbital prefrontal cortex in which contingencies are learned and then reversed. Finally, participants completed the transverse patterning task (TPT), a memory experiment that is an adaption of the ‘rock/paper/scissors problem’, that has been shown to depend on the hippocampus. Results: Regression analyses revealed that better TPT scores significantly predicted better performance on MMAA (p = .01) whereas RT scores had no relation (p = .39). However, TP and RT were not significantly related (p = .21), suggesting they may measure different constructs. Conclusion: Contrary to our predictions, results suggest that the memory domain dependent on the hippocampus, as measured by TPT, contributes largely to medication management in normal populations. Our findings suggest that TPT may be useful in predicting and detecting impairments in medication management and medication adherence in clinical populations before receiving pharmaceutical prescriptions.
A Preliminary Analysis of Memory and Executive Function Contributions to a Medication Management Task in Healthy, Young Adults
E Gracian, M Austiff, K Mosack; C-53
A Preliminary Analysis of Memory and Executive Function Contributions to a Medication Management Task in Healthy, Young Adults. Arch Clin Neuropsychol 2015; 30 (6): 582. doi: 10.1093/arclin/acv047.255
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