Objective: The purpose of this study was to quantify associations between WAIS-IV Indexes and specific cognitive domains on the CNS Vital Signs (CNSVS) computerized battery. Method: Data from 228 undergraduate participants were used. Demographics: 70% white, 23% African American, 5% Asian, 2% other, and 55% female; mean age 21 years (SD 5.4). All participants completed the WAIS-IV and CNSVS. Normed scores were used for all analyses. Participants were divided into a high IQ group above 100 (n = 140) and low IQ group below 100 (n = 94). Results: Significant correlations were found between Full Scale IQ and the following CNS Vital Signs domains: psychomotor speed (r = .26), reaction time (r = .14), complex attention (r = .21), cognitive flexibility (r = .30), processing speed (r = .34), executive functioning (r = .30), visual memory (r = .24), and neurocognitive index (r = .38). WAIS-IV Working Memory Index was correlated with the following: psychomotor speed (r = .29), cognitive flexibility (r = .13), executive functioning (r = .14), and neurocognitive index (r = .15). WAIS-IV Processing Speed Index was correlated with the following: psychomotor speed (r = .17), reaction time (r = .27), complex attention (r = .17), cognitive flexibility (r = .33), processing speed (r = .44), executive functioning (r = .34), and neurocognitive index (r = .33). ANOVA revealed significant differences between high and low IQ groups for CNSVS complex attention, cognitive flexibility, processing speed, executive functioning, visual memory, and neurocognitive index with the high IQ group always performing better. Conclusion: WAIS-IV Full Scale IQ was positively associated with all CNSVS domains demonstrating positive manifold. WAIS-IV Working Memory had surprisingly weak associations with CNSVS domains while WAIS-IV Processing Speed was strongly associated to many of the CNSVS domains.