Objective: Few studies have examined the relationship between validity indicators of neuropsychological performance and the Personality Assessment Inventory (PAI). The present study explored the relationship between Word Memory Test (WMT) performance and PAI validity. Method: Subjects were 75 outpatients (Mean/SD: age = 47.47/13.256, education = 14.20/2.511) referred to a neurology/neuropsychological clinic and evaluated with the PAI and a neuropsychological battery including measures of visuospatial/construction ability, language, attention, memory and executive functions. Pearson's r coefficients were calculated for WMT subtests and validity indices of the PAI: Inconsistency (INC), Infrequency (INF), Negative Impression Management (NIM), Positive Impression Management (PIM), Defensiveness, Cashel Discriminant Function (CDF), Malingering, and Rogers Discriminant Function (RDF). Results: Correlations were significant for NIM and the following WMT scores (all p's < .05): Immediate Recall (r = −.345), Delayed Recall (r = −.320), Consistency (r = −.250), and Multiple Choice (r = −.238). CDF was significantly correlated with WMT Multiple Choice (r = −.234, p = .047) and Paired Associates (r = −.289, p = .013). Correlations remained significant after correcting for age and education. Conclusion: NIM had significant negative correlations with all performance validity indices and the Multiple Choice scale of the WMT. Furthermore, CDF had significant negative correlations with Multiple Choice and Paired Associate scales of the WMT. These findings indicate that the tendency to emphasize or exaggerate symptoms on the PAI is associated with lower scores on performance validity and memory measures of the WMT, although these associations were modest.