Objective: Some versions of the Stroop Test (e.g., Comalli version; see Arentsen et al., 2013) have effectively detected negative response bias for neuropsychological evaluations. The current study examined the utility of subtests from the Delis-Kaplan Executive Function System (D-KEFS) Color-Word Interference Test as a Performance Validity Test (PVT). Method: Color Naming (CN) and Word Reading (WR) raw scores were examined for noncredible (n = 32) and credible (n = 110) patients from a Veterans Affairs Medical Center (Age < 70 years). Patients were considered credible if they were administered >3 PVTs, all PVT performances fell within normal limits, and with no diagnosis of Major Neurocognitive Disorder or Intellectual Disability. Patients were considered non-credible if they failed >2 PVTs and were administered < 5 tests or failed >3 PVTs and were administered < 7 PVTs. Receiver operating characteristic (ROC) curve analyses were conducted to discriminate between credible and non-credible groups. Results: Both CN performance, F(1, 139) = 37.3.2, p < .001, η2 = .21, and WR performance, F(1, 140) = 38.5, p < .001, η2 = .22, distinguished response bias with credible performances being quicker than non-credible performances for CN (M = 33.0, SD = 9.5 vs. M = 45.3, SD = 11.6 seconds respectively) and WR (M = 25.7, SD = 8.1 vs. M = 36.2, SD = 9.4 seconds respectively). When specificity was set at >90%, a cut-score on CN at >44 seconds yielded sensitivity at 56.3%. A cut-score on WR at >34 seconds yielded sensitivity at 53.1%. Conclusion: D-KEFS CN and WR performances function as moderately sensitive PVTs in a clinical, VA setting for patients below the age of 70 years.