Objective: Technological advances have enabled the development of neuropsychological (NP) measures for use on mobile devices. The goal of this study was to establish the initial test-retest reliability and validity of NP measures designed for the iPad format. Method: 72 participants completed measures designed for the iPad; 35 retook the battery 3 months later. The battery is self-administered (instructions via written, audio, and visual methods), < 20 minutes, and includes measures analogous to common NP measures: Spatial Span (SS), Trail Making Test (TMT), Stroop, Digit Symbol (DS), and visual learning (Visual Spatial Learning Tests, VSLT). 31 participants also completed traditional NP assessments. Average age was 48.4 (sd = 12.0) years with 13.4 years of education (sd = 2.4). 82% were male, 79% were HIV + , 44% were ethnic minorities. Results: Test-retest correlations were large (all p < .001) for DS (r = .85), Stroop (Word r = .90, Color r = .88, Interference r = .85), and VSLT (Total r = .86, Delayed r = .85), with modest correlations for TMT (A r = .59, B r = .70), and SS (r = .44, p < .01). HIV+ and HIV- had generally similar correlations except for SS. Correlations between iPad measures and similar NP tests were moderate (all p < .001) for DS (r = .71), SS (r = .69), TMT B (r = .66), and VSLT (Total Learning r = .62, p = .02; Delayed Recall r = .55, p = .05), Stroop (Word r = .55, Color r = .57, Interference r = .65), and SS (r = .45, p = .01). Conclusion: Findings support preliminary test-retest reliability and construct validity of the iPad measures. These measures may prove efficient in the detection of cognitive impairments in clinical settings, including tracking changes over time, where comprehensive NP assessments may be unavailable due to time and resource limitations.