Objective: The Comprehensive Trail-Making Test (CTMT) is sensitive to brain injury and successful performance requires a variety of cognitive abilities. However, little research has examined neurocognitive abilities that influence CTMT performance in clinical populations. Research indicates CTMT simple sequencing (SS) and complex sequencing (CS) factors differ between clinical and non-clinical populations, supporting the need for validity studies of CTMT scores in clinical populations. This study extends prior research by examining neurocognitive correlates that underlie performance on CTMT factor scores in a large sample of children with neurological disorders. Method: The sample consisted of 98 children with various neurological disorders, primarily TBI (n = 71) or AVM/Stroke (n = 10). They were 14.7 years old and 65.3% male. Glasgow coma scale scores of children with TBI indicated severe brain injuries (GCS = 6.0). Participants were selected from a consecutive series of cases refereed for neuropsychological assessment and included if administered the CTMT and measures of possessing speed, working memory, motor speed, and sustained attention. Relationship between neurocognitive correlates and CTMT factor scores were examined using multiple regression. Results: Results indicate the SS factor was predicted by processing speed, fine motor speed, and hyperactivity/impulsivity, while the CS factor was predicted by processing speed, fine motor speed, and working memory. Conclusion: Consistent with prior research on the original TMT and the more recent CTMT, current results indicate that CS relies more heavily on working memory abilities than SS. These results aid in establishing validity of the CTMT factors and further its utility when used to assess children with brain disorders.