Objective: Freezing of gait (FOG) can be a debilitating symptom in Parkinson's disease (PD) and has a major impact on quality of life. Anxiety may be associated with FOG in PD, but it is unknown whether other mood symptoms also contribute. Furthermore, the relationship between FOG and global cognition is not clearly defined. We examined whether anxiety, depression, apathy, or global cognition were unique predictors of FOG in patients with PD. Method: A convenience sample of 147 PD patients was classified as either having FOG (n = 35) or no FOG (n = 112) based on their responses on the Unified Parkinson's Disease Rating Scale (UPDRS). Logistic regression was used to predict FOG (present or absent) based on scores from the state scale of the State Trait Anxiety Inventory (STAI-S), the Geriatric Depression Scale (GDS), the Apathy Scale (AS), and the Mattis Dementia Rating Scale (MDRS). Results: The overall model was found to be a good fit of the data, [χ2(3) = 16.8, p = 0.002], but the total amount of variance accounted for was modest, 16.2%. Only greater STAI-S scores [B = 0.07, p = 0.011] were significant predictors of FOG, whereas GDS scores [B = -0.053, p = 0.32], AS scores [B = 0.048, p = 0.31], and MDRS scores [B = -0.058, p = 0.25] were not. Conclusion: Anxiety symptoms were found to predict FOG in PD patients, whereas levels of depression, apathy, and global cognition were not associated. While the relationship between anxiety and FOG was modest, the finding that anxiety can impact motor symptoms in PD warrants further study to determine if the treatment of anxiety can improve gait in this population.
Predictors of Freezing of Gait in Parkinson's Disease: The Influence of Mood and Cognition
L Nguyen, C Pluim, D Schiehser, E Turk, S Lessig, D Song, I Litvan, J Filoteo; C-61
Predictors of Freezing of Gait in Parkinson's Disease: The Influence of Mood and Cognition. Arch Clin Neuropsychol 2016; 31 (6): 663. doi: 10.1093/arclin/acw043.210
Download citation file:
© 2017 Oxford University Press×