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Sidney Trubowitz, Oscar Frank, Herman Baker, Survey of vitamin B12 and folate in the serum and marrow tissue of hospitalized patients, The American Journal of Clinical Nutrition, Volume 27, Issue 6, June 1974, Pages 580–583, https://doi.org/10.1093/ajcn/27.6.580
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ABSTRACT
The sera and marrow tissues from 47 patients were assayed for their folate and vitamin B12 content. The mean marrow folate and B12 was 135.6 pg/mg and 14.6 pg/mg wet weight of marrow, respectively. Results suggest a size relationship between folate and B12 pools in the serum and marrow with a constant folate/B12 ratio. The ratio of the mean serum folate/mean serum B12 is 9.8 and the mean marrow folate/mean marrow B12 is 9.2. Re-expressed, the mean serum B12/mean marrow B12 is equal to the mean serum folate/mean marrow folate, indicating a similar partition of these two vitamins between serum and marrow. Correlation between serum folate levels and marrow folate levels is poor. Similarly, poor correlation was found between serum and marrow B12.
