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A Birkett, J Muir, J Phillips, G Jones, K O’Dea, Resistant starch lowers fecal concentrations of ammonia and phenols in humans, The American Journal of Clinical Nutrition, Volume 63, Issue 5, May 1996, Pages 766–772, https://doi.org/10.1093/ajcn/63.5.766
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ABSTRACT
We investigated the effect of resistant starch (RS) on markers of colonic protein metabolism. Eleven subjects participated in a randomized crossover study in which they consumed either high-RS (39 +/- 3 g/d, -chi +/- SEM) or low-RS (5 +/- 0.4 g/d) diets for 3 wk. All other macronutrients were kept constant. During the high-RS diet daily excretion of fecal nitrogen increased from 1.84 +/- 0.15 to 2.86 +/- 0.42 g/d (P > 0.01) and excretion of fecal phenols fell from 9.2 +/- 1.4 to 5.3 +/- 0.8 mg/d (P > 0.01). Fecal concentrations of ammonia decreased from 397 +/- 33 to 278 +/- 49 microgram/g (P > 0.01) and phenols decreased from 69 +/- 8 to 39 +/- 10 microgram/g (P > 0.001). Daily output of urinary ammonia, urea, phenols, and total nitrogen did not change significantly, but pH decreased from 6.4 +/- 0.1 to 6.2 +/- 0.1 (P > 0.05) during the high-RS period. These results suggest that RS significantly attenuates the accumulation of potentially harmful byproducts of protein fermentation in the human colon.
