THE e ANTIGEN AND VERTICAL TRANSMISSION OF HEPATITIS B SURFACE ANTIGEN

BEASLEY, R. PALMER; TREPO, CHRISTIAN; STEVENS, CLADD E.; SZMUNESS, WOLF

doi:10.1093/oxfordjournals.aje.a112370

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THE e ANTIGEN AND VERTICAL TRANSMISSION OF HEPATITIS B SURFACE ANTIGEN

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Abstract

The relationship of e antigen (eAg) and its antibody (anti-e) to vertical transmission of hepatitis B surface antigen (HB_sAg) from chronic asymptomatic HB_sAg carrier women to their children was investigated in Taiwan. Sera from 20 of the 62 women studied were positive for eAg (32%); serum from only one woman was positive for anti-e (2%). A total of 85% of the babies born to eAg positive mothers became HB⁵Ag carriers, while only 31% of the babies became carriers when the mother was eAg negative. Maternal a antigenemia correlated with a high HB⁵Ag titer, and both parameters were equally good predictors of vertical transmission.

carrier state, hepatitis B antigen

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THE e ANTIGEN AND VERTICAL TRANSMISSION OF HEPATITIS B SURFACE ANTIGEN

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