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The World Health Organization estimates that 1 in every 8 people in the world lives with a psychiatric disorder, with a 13% rise in psychiatric disorders and substance use seen in just the past decade.  The 2 most common psychiatric disorders, depression and anxiety, cost the global economy $1 trillion a year. In the United States, the Centers for Disease Control and Prevention estimates that more than 1 in 5 adults lives with a psychiatric disorder, and approximately 1 in 25 adults lives with serious mental illness (e.g., schizophrenia, bipolar disorder, major depression). Despite these striking statistics, the World Health Organization reports that the median global governmental expenditure on mental health is only 2%.  Although great strides have been made in the understanding of many areas of physical health over the past several decades, it can be argued that the same strides have not been made in the understanding of mental health.  This could be attributed to several factors, including the inherent challenges related to studying brain function, a largely crisis-based mental health–care system (particularly in the United States) that does not prioritize or enable the study of prevention, and widespread stigma that has made mental health issues less acceptable to disclose than physical health issues, thereby hindering our understanding of what it means to struggle with mental health.  It is also important to note that mental health and social factors are inextricably linked. Psychiatric disorders are not evenly distributed within populations, and like many health conditions, it is often the most structurally marginalized communities, both historically and currently, who bear the harshest burden of these disorders. Insofar as advancements in psychiatry have been particularly slow compared with those in other areas of health, it is important to reflect on how subpopulations affected by these disorders may not be those that we have chosen to prioritize for research and innovation.  Given this current context, there has never been a more important time for a special collection focused on mental health in the American Journal of Epidemiology.  Papers selected for inclusion in this collection present cutting-edge research in mental health in various forms—from new examinations of standing complex problems, to a focus on marginalized populations, to methods innovation. We hope this collection of articles is the first step in propelling the field toward overdue advancements in psychiatric epidemiology.

Jaimie L. Gradus and John R. Pamplin II, Guest Editors

The Papers

Assessing mental health treatment receipt among Asian adults with limited English proficiency using an intersectional approach
Charlie H Nguyễn and others
American Journal of Epidemiology, Volume 193, Issue 10, October 2024, Pages 1343–1351, https://doi.org/10.1093/aje/kwae042
Published: 23 May 2024
US Asian adults and people with limited English proficiency (LEP) confront mental health treatment receipt disparities. At the intersection of racial and language injustice, Asian adults with LEP may face even greater disparity, but studies have not assessed this through explicitly intersectional ...
Three things we learned along the way: lessons for training in psychiatric epidemiology
Alisa K Lincoln and others
American Journal of Epidemiology, Volume 193, Issue 10, October 2024, Pages 1318–1321, https://doi.org/10.1093/aje/kwae123
Published: 17 June 2024
The coronavirus disease 2019 (COVID-19) pandemic, and its associated mortality, morbidity, and deep social and economic impacts, was a global traumatic stressor that challenged population mental health and our de facto mental health care system in unprecedented ways. Yet, in many respects, this ...
Antipsychotic drugs in first-episode psychosis: a target trial emulation in the FEP-CAUSAL Collaboration
Alejandro G Szmulewicz and others
American Journal of Epidemiology, Volume 193, Issue 8, August 2024, Pages 1081–1087, https://doi.org/10.1093/aje/kwae029
Published: 03 April 2024
Good adherence to antipsychotic therapy helps prevent relapses in first-episode psychosis (FEP). We used data from the FEP-CAUSAL Collaboration, an international consortium of observational cohorts, to emulate a target trial comparing antipsychotics, with treatment discontinuation as the primary ...
Machine learning for detection of heterogeneous effects of Medicaid coverage on depression
Ryunosuke Goto and others
American Journal of Epidemiology, Volume 193, Issue 7, July 2024, Pages 951–958, https://doi.org/10.1093/aje/kwae008
Published: 22 February 2024
In 2008, Oregon expanded its Medicaid program using a lottery, creating a rare opportunity to study the effects of Medicaid coverage using a randomized controlled design (Oregon Health Insurance Experiment). Analysis showed that Medicaid coverage lowered the risk of depression. However, this effect ...
Invited commentary: mental health services utilization disparities at the intersection of Asian ethnoracial identity and limited English proficiency
Jenny Zhen-Duan and Alexander C Tsai
American Journal of Epidemiology, Volume 194, Issue 4, April 2025, Pages 941–945, https://doi.org/10.1093/aje/kwae112
Published: 12 June 2024
Nguyễn et al. ( Am J Epidemiol. 2024;193(10):1343-1351) analyzed data from the US National Survey of Drug Use and Health (NSDUH) to show that Asian American Native Hawaiian/Pacific Islander (AANHPI) adults with limited English proficiency have substantially lower levels of mental health services ...
Venkatapuram responds to “Positive epidemiology, revisited: the case for centering human rights and economic justice”
Sridhar Venkatapuram
American Journal of Epidemiology, Volume 194, Issue 4, April 2025, Pages 1140–1142, https://doi.org/10.1093/aje/kwae281
Published: 14 August 2024
This commentary responds to the article by Qureishi et al ( Am J Epidemol . 2024;193(10):1313–1317) that criticizes a new proposal for “positive epidemiology.” They argue that positive epidemiology, as it is being proposed and conducted, ignores supraindividual social contextual factors that ...
Invited commentary: “Neighborhood eviction trajectories and odds of moderate and serious psychological distress during pregnancy among African American women”
Patrece L Joseph and others
American Journal of Epidemiology, Volume 194, Issue 4, April 2025, Pages 921–924, https://doi.org/10.1093/aje/kwae290
Published: 27 August 2024
This article is part of a Special Collection on Mental Health. Editor’s note: The opinions expressed in this article are those of the authors and do not necessarily reflect the views of the American Journal of Epidemiology. The article titled “Neighborhood eviction trajectories and odds of ...
Estimation of the prevalence of opioid misuse in New York State counties, 2007-2018: a bayesian spatiotemporal abundance model approach
Julian Santaella-Tenorio and others
American Journal of Epidemiology, Volume 193, Issue 7, July 2024, Pages 959–967, https://doi.org/10.1093/aje/kwae018
Published: 06 March 2024
An important challenge to addressing the opioid overdose crisis is the lack of information on the size of the population of people who misuse opioids (PWMO) in local areas. This estimate is needed for better resource allocation, estimation of treatment and overdose outcome rates using appropriate ...
Invited commentary: policies that support working parents and gender health equity—needed research and methodological challenges
Alina Schnake-Mahl and Jaquelyn Jahn
American Journal of Epidemiology, Volume 194, Issue 2, February 2025, Pages 331–335, https://doi.org/10.1093/aje/kwae223
Published: 16 July 2024
In a recent issue of the Journal , Platt et al ( Am J Epidemiol . 2024;193(10):1362-1371) shed new light on the potential for supportive employment benefits, including family leave, flexible work hours, and employer-provided or subsidized childcare, to mitigate the risk of depression among ...
An examination of sleep as a protective factor for depression and anxiety in the perinatal period: novel causal analyses in a prospective pregnancy cohort
Archana Basu and others
American Journal of Epidemiology, kwae349, https://doi.org/10.1093/aje/kwae349
Published: 11 September 2024
Sleep problems are common in the perinatal period. But the effects of sleep health on long-term postpartum depression and anxiety are underexamined. Using marginal structural models, we estimated the effect of sustained restful sleep quality, or adequate sleep quantity, or both, on clinically ...
Geographic Variation, Economic Activity, and Labor Market Characteristics in Trajectories of Suicide in the United States, 2008–2020
Katherine M Keyes and others
American Journal of Epidemiology, Volume 193, Issue 2, February 2024, Pages 256–266, https://doi.org/10.1093/aje/kwad205
Published: 16 October 2023
Suicide rates in the United States have increased over the past 15 years, with substantial geographic variation in these increases; yet there have been few attempts to cluster counties by the magnitude of suicide rate changes according to intercept and slope or to identify the economic precursors ...
Considerations for Use of Blood-Based Biomarkers in Epidemiologic Dementia Research
Eleanor Hayes-Larson and others
American Journal of Epidemiology, Volume 193, Issue 3, March 2024, Pages 527–535, https://doi.org/10.1093/aje/kwad197
Published: 16 October 2023
Dementia represents a growing public health burden with large social, racial, and ethnic disparities. The etiology of dementia is poorly understood, and the lack of robust biomarkers in diverse, population-representative samples is a barrier to moving dementia research forward. Existing biomarkers ...
Suicide Mortality Among Formerly Incarcerated People Compared With the General Population in North Carolina, 2000–2020
Kate Vinita Fitch and others
American Journal of Epidemiology, Volume 193, Issue 3, March 2024, Pages 489–499, https://doi.org/10.1093/aje/kwad214
Published: 03 November 2023
We aimed to compare rates and characteristics of suicide mortality in formerly incarcerated people with those of the general population in North Carolina. We conducted a retrospective cohort study of 266,400 people released from North Carolina state prisons between January 1, 2000, and March 1, ...
Re: Estimation of opioid misuse prevalence in New York State counties, 2007-2018. A Bayesian spatio-temporal abundance model approach
Heather Bradley and others
American Journal of Epidemiology, Volume 194, Issue 3, March 2025, Pages 867–868, https://doi.org/10.1093/aje/kwae407
Published: 28 January 2025
This article is part of a Special Collection on Mental Health. We read with interest the article by Santaella-Tenorio et al. 1 in which the authors estimate opioid misuse (OM) prevalence in New York State (NYS) counties by modeling publicly releasable, summarized surveillance data. Estimating ...
Joint effects of indoor air pollution and maternal psychosocial factors during pregnancy on trajectories of early childhood psychopathology
Grace M Christensen and others
American Journal of Epidemiology, Volume 193, Issue 10, October 2024, Pages 1352–1361, https://doi.org/10.1093/aje/kwae046
Published: 17 April 2024
Prenatal indoor air pollution and maternal psychosocial factors have been associated with adverse psychopathology. We used environmental-exposure mixture methodology to investigate joint effects of both exposure classes on child behavior trajectories. For 360 children from the South African ...
Assessing trends in internalizing symptoms among racialized and minoritized adolescents: results from the Monitoring the Future Study 2005-2020
Navdep Kaur and others
American Journal of Epidemiology, Volume 193, Issue 11, November 2024, Pages 1519–1529, https://doi.org/10.1093/aje/kwae024
Published: 21 March 2024
The prevalence of depressive symptoms has rapidly accelerated among recent US adolescent birth cohorts, yet there remains little understanding of trends among racialized and minoritized groups. These groups may experience depressive symptoms due to the deleterious effects of structural racism. ...
Key considerations for the future of mental health epidemiology
Salma M Abdalla and Sandro Galea
American Journal of Epidemiology, Volume 193, Issue 10, October 2024, Pages 1307–1312, https://doi.org/10.1093/aje/kwae114
Published: 12 June 2024
Psychiatric epidemiology has led to substantial progress in our understanding of the causes of mental health disorders. The increasing sophistication of etiologic psychiatric research has been accompanied by a greater focus on the biological and genetic causes of psychiatric disorders, to some ...
Improving prevalence estimates of mental health and well-being indicators among sexual minority men: a propensity-weighting approach
Christoffer Dharma and others
American Journal of Epidemiology, Volume 193, Issue 12, December 2024, Pages 1758–1767, https://doi.org/10.1093/aje/kwae107
Published: 06 June 2024
The prevalence and relative disparities of mental health outcomes and well-being indicators are often inconsistent across studies of sexual minority men (SMM) due to selection biases in community-based surveys (nonprobability sample), as well as misclassification biases in population-based surveys ...
A hypothetical intervention to reduce inequities in anxiety for Multiracial people: simulating an intervention on childhood adversity
Tracy Lam-Hine and others
American Journal of Epidemiology, Volume 193, Issue 12, December 2024, Pages 1750–1757, https://doi.org/10.1093/aje/kwae095
Published: 29 May 2024
Multiracial people report higher mean Adverse Childhood Experience (ACE) scores and prevalence of anxiety than other racial groups. Studies using statistical interactions to test if associations between ACEs and anxiety are greater for this group than others have shown mixed results. Using data ...
Suicide deaths involving opioid poisoning in the United States, by sex, 1999-2021
Rachel A Hoopsick and others
American Journal of Epidemiology, Volume 193, Issue 11, November 2024, Pages 1511–1518, https://doi.org/10.1093/aje/kwae094
Published: 29 May 2024
Suicide remains a leading cause of death in the United States, and recent data suggest suicide deaths involving opioids are increasing. Given unprecedented increases in drug-poisoning deaths, suicidality, and suicide deaths in recent years, an updated examination of the trends in suicide deaths ...
Moving From Traumatic Events to Traumatic Experiences in the Study of Traumatic Psychopathology
Jaimie L Gradus and Sandro Galea
American Journal of Epidemiology, Volume 192, Issue 10, October 2023, Pages 1609–1612, https://doi.org/10.1093/aje/kwad126
Published: 22 May 2023
Trauma is defined in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) as an event that includes “actual or threatened death, serious injury, or sexual violence” (p. 271). The list of traumatic events included in the DSM-5 represents a long history of psychiatry and ...
Racialized experience, biomarkers of lead exposure, and later-life cognition: a mediation analysis
Tara E Jenson and others
American Journal of Epidemiology, Volume 194, Issue 2, February 2025, Pages 420–431, https://doi.org/10.1093/aje/kwae194
Published: 20 July 2024
We evaluated the role of the neurotoxicant lead (Pb) in mediating racial disparities in later-life cognition in 1085 non-Hispanic Black and 2839 non-Hispanic white participants in the National Health and Nutrition and Examination Survey (NHANES, 1999-2002, 2011-2014) 60+ years of age. We ...
Investigating a Paradox: Toward a Better Understanding of the Relationships Between Racial Group Membership, Stress, and Major Depressive Disorder
John R Pamplin II and others
American Journal of Epidemiology, Volume 192, Issue 11, November 2023, Pages 1845–1853, https://doi.org/10.1093/aje/kwad128
Published: 25 May 2023
Epidemiologic studies in the United States routinely report a lower or equal prevalence of major depressive disorder (MDD) for Black people relative to White people. Within racial groups, individuals with greater life stressor exposure experience greater prevalence of MDD; however, between racial ...
Translating Predictive Analytics for Public Health Practice: A Case Study of Overdose Prevention in Rhode Island
Bennett Allen and others
American Journal of Epidemiology, Volume 192, Issue 10, October 2023, Pages 1659–1668, https://doi.org/10.1093/aje/kwad119
Published: 17 May 2023
Prior applications of machine learning to population health have relied on conventional model assessment criteria, limiting the utility of models as decision support tools for public health practitioners. To facilitate practitioners’ use of machine learning as a decision support tool for area-level ...
Re: “Invited commentary: influence of incomplete death information on cumulative risk estimates”
Julie Barberio and others
American Journal of Epidemiology, kwae229, https://doi.org/10.1093/aje/kwae229
Published: 03 January 2025
This article is part of a Special Collection on Pharmacoepidemiology. We are grateful for the opportunity to provide an additional discussion of our study, which highlighted the methodological challenge of missing death information in United States claims databases. 1 The main finding from our ...
Depression at the intersection of race/ethnicity, sex/gender, and sexual orientation in a nationally representative sample of US adults: a design-weighted intersectional MAIHDA
F Hunter McGuire and others
American Journal of Epidemiology, Volume 193, Issue 12, December 2024, Pages 1662–1674, https://doi.org/10.1093/aje/kwae121
Published: 14 June 2024
This study examined how race/ethnicity, sex/gender, and sexual orientation intersect under interlocking systems of oppression to socially pattern depression among US adults. With cross-sectional data from the 2015-2020 National Survey on Drug Use and Health ( n = 234 722), we conducted a ...
Cognitive behavioral program for the prevention of depression in at-risk adolescents: isolating the effects of dose
John F Dickerson and others
American Journal of Epidemiology, Volume 194, Issue 1, January 2025, Pages 19–26, https://doi.org/10.1093/aje/kwae131
Published: 20 June 2024
The current study estimated effects of intervention dose (attendance) of a cognitive behavioral prevention (CBP) program on depression-free days (DFDs) in adolescent offspring of parents with a history of depression. As part of secondary analyses of a multisite randomized controlled trial, we ...
The InterSECT Framework: a proposed model for explaining population-level trends in substance use and emotional concerns
Jillian Halladay and others
American Journal of Epidemiology, Volume 193, Issue 8, August 2024, Pages 1066–1074, https://doi.org/10.1093/aje/kwae013
Published: 22 February 2024
Across high-income countries, adolescent emotional concerns have been increasing in prevalence over the past two decades and it is unclear why this is occurring, including whether and how substance use relates to these changing trends. On the other hand, substance use has been generally declining, ...
The role of prescription opioid and cannabis supply policies on opioid overdose deaths
Magdalena Cerdá and others
American Journal of Epidemiology, Volume 194, Issue 3, March 2025, Pages 791–801, https://doi.org/10.1093/aje/kwae210
Published: 18 July 2024
Mandatory prescription drug monitoring programs and cannabis legalization have been hypothesized to reduce overdose deaths. We examined associations between prescription monitoring programs with access mandates (must-query PDMPs), legalization of medical and recreational cannabis supply, and opioid ...
Prediction of suicide attempts among persons with depression: a population-based case cohort study
Tammy Jiang and others
American Journal of Epidemiology, Volume 193, Issue 6, June 2024, Pages 827–834, https://doi.org/10.1093/aje/kwad237
Published: 05 December 2023
Studies have highlighted the potential importance of modeling interactions for suicide attempt prediction. This case-cohort study identified risk factors for suicide attempts among persons with depression in Denmark using statistical approaches that do (random forests) or do not (least absolute ...
The Mental Health Consequences of George Floyd’s Murder in Minneapolis in Black, Latine, and White Communities
N Jeanie Santaularia and others
American Journal of Epidemiology, kwae359, https://doi.org/10.1093/aje/kwae359
Published: 13 September 2024
The high-profile police murder of George Floyd is likely to have an aftermath of negative health consequences, particularly among Black people. Our study evaluates the impact of the murder of Mr. Floyd on mental health in Black, Latine, and white communities in Minneapolis, Minnesota. We ...
Neighborhood eviction trajectories and odds of moderate and serious psychological distress during pregnancy among African American women
Shawnita Sealy-Jefferson and others
American Journal of Epidemiology, Volume 193, Issue 7, July 2024, Pages 968–975, https://doi.org/10.1093/aje/kwae025
Published: 22 March 2024
African American mothers are unjustly burdened by both residential evictions and psychological distress. We quantified associations between trajectories of neighborhood evictions over time and the odds of moderate and serious psychological distress (MPD and SPD, respectively) during pregnancy among ...
Positive epidemiology, revisited: the case for centering human rights and economic justice
Farah Qureshi and others
American Journal of Epidemiology, Volume 193, Issue 10, October 2024, Pages 1313–1317, https://doi.org/10.1093/aje/kwae056
Published: 22 April 2024
In recent years, a growing body of research in positive epidemiology has sought to expand the traditional focus of epidemiologic research beyond risk factors for disease and towards a more holistic understanding of health that includes the study of positive assets that shape well-being more ...
Bringing home the benefits: do pro-family employee benefits mitigate the risk of depression from competing workplace and domestic labor roles?
Jonathan M Platt and others
American Journal of Epidemiology, Volume 193, Issue 10, October 2024, Pages 1362–1371, https://doi.org/10.1093/aje/kwae055
Published: 26 April 2024
Despite significant historical progress toward sex/gender parity in employment status in the United States, women remain more likely to provide domestic labor, creating role competition which may increase depression symptoms. Pro-family employee benefits may minimize the stress of competing roles. ...
State-level structural racism and adolescent mental health in the United States
Paris B Adkins-Jackson and others
American Journal of Epidemiology, Volume 194, Issue 4, April 2025, Pages 946–953, https://doi.org/10.1093/aje/kwae164
Published: 03 July 2024
We explored state-level indicators of structural racism on internalizing symptoms of depressive affect among US adolescents. We merged 16 indicators of state-level structural racism with 2015-19 Monitoring the Future surveys ( n = 41 258) examining associations with loneliness, self-esteem, ...
School racial/ethnic composition, effect modification by caring teacher/staff presence, and mid-/late-life depressive symptoms: findings from the Study of Healthy Aging in African Americans
Taylor M Mobley and others
American Journal of Epidemiology, Volume 193, Issue 9, September 2024, Pages 1253–1260, https://doi.org/10.1093/aje/kwae050
Published: 17 April 2024
For Black students in the United States, attending schools with a higher proportion of White students is associated with worse mental and physical health outcomes in adolescence/early adulthood. To our knowledge, no prior studies have evaluated the association between school racial/ethnic ...
Using unsupervised clustering approaches to identify common mental health profiles and associated mental health-care service-use patterns in Ontario, Canada
Christa Orchard and others
American Journal of Epidemiology, Volume 193, Issue 7, July 2024, Pages 976–986, https://doi.org/10.1093/aje/kwae030
Published: 03 April 2024
Mental health is a complex, multidimensional concept that goes beyond clinical diagnoses, including psychological distress, life stress, and well-being. In this study, we aimed to use unsupervised clustering approaches to identify multidimensional mental health profiles that exist in the ...
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