Thursday, 5/18, Rendezvous Trianon, 5:00 pm–7:00 pm Theme I: Altered Cellular Ion Regulation in Hypertension
THE LINKS BETWEEN CELLULAR Ca²⁺ AND THE Na⁺/H⁺ ANTIPORT IN THE PATHOPHYSIOLOGY OF ESSENTIAL HYPERTENSION

Sodium, calcium, ion transport, essential hypertension

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Essential hypertension is marked by dysfunctional regulation (dysregulation) of Ca²⁺ and Na⁺ at the cellular level. Since essential hypertension is a polygenic disorder, ionic dysregulation may independently arise from primary abnormalities in regulatory pathways of Ca²⁺ and Na⁺. Alternatively, primary abnormalities resulting from the regulation of one of these ions may be expressed by secondary (adaptive) alterations in the regulations of the other ion. Understanding the links between the regulatory elements of cellular Ca²⁺ and Na⁺ is therefore the key to deciphering the underlying etiology of dysfunctional Ca²⁺ and Na⁺ regulation in essential hypertension. Moreover, the distinction between primary vs secondary ionic dysregulation is a crucial step in elucidating the genetic origin of essential hypertension. Recent studies have...