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Sante D. Pierdomenico, Fabrizio Costantini, Anna Bucci, Domenico De Cesare, Tonino Bucciarelli, Franco Cuccurullo, Andrea Mezzetti; Blunted nocturnal fall in blood pressure and oxidative stress in men and women with essential hypertension: , American Journal of Hypertension, Volume 12, Issue S3, 1 April 1999, Pages 356–363, https://doi.org/10.1016/S0895-7061(00)86961-7
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Abstract
Low-density lipoprotein oxidation and antioxidant vitamins E and C were investigated in dipper (nocturnal blood pressure fall > 10%) and nondipper (nocturnal blood pressure fall < 10%) hypertensives. We studied 40 dippers and 28 nondippers balanced for gender, age, and body mass index. Blood samples were drawn for lipid profile determination, assessment of thiobarbituric acid-reactive substances, and fluorescent products of lipid peroxidation in native low-density lipoprotein, evaluation of susceptibility to low-density lipoprotein oxidation in vitro (lag phase and propagation rate), and determination of low-density lipoprotein vitamin E and plasma vitamins E and C contents. Compared with dippers, nondippers had significantly higher thiobarbituric acid-reactive substances and fluorescent products of lipid peroxidation (0.63 ± 0.1 v 0.77 ± 0.08 nmol malondialdehyde/mg low-density lipoprotein protein, and 14.5 ± 6 v 17.9 ± 4 units of relative fluorescence/mg low-density lipoprotein protein, respectively, both P <.05), shorter lag phase (56 ± 13 v 49 ± 9 min, P <.05), and lower plasma vitamin C content (42 ± 9 v 35 ± 10 μmol/L, P <.05). When gender was taken into account, differences were not significant between dipper and nondipper men, whereas, compared with dipper women, nondipper women showed significantly higher thiobarbituric acid-reactive substances and fluorescent products of lipid peroxidation (0.56 ± 0.1 v 0.77 ± 0.07 nmol malondialdehyde/mg low-density lipoprotein protein, and 12.5 ± 4 v 17.5 ± 4.6 units of relative fluorescence/mg low-density lipoprotein protein, respectively, both P < .05), shorter lag phase (62.5 ± 11 v 49 ± 9.5 min, P < .05), and lower plasma vitamin C content (44.9 ± 10 v 34.7 ± 10.8 μmol/L, P < .05). Given the role of low-density lipoprotein oxidation in the pathogenesis of atherosclerosis and that of vitamin C in protecting against it, our data suggest that nondippers, especially among women, show higher atherogenic risk than dippers. Am J Hypertens 1999;12:356–363 © 1999 American Journal of Hypertension, Ltd.
