P-217: Blood pressure control does not ensure the control of microalbuminuria in previously untreated hypertension

Abstract

The aim of this study was to investigate the prevalence of microalbuminuria (MA) in 502 newly diagnosed and never treated essential hypertensives (EH) (mean age 58 + 12 y, 54.7% female) and the effect of treatment during a follow-up of 3 month with either ramipril R (5-10 mg od) or atenolol (A) (50-100 mg od) on those with MA (+). MA was measured in a central laboratory in 3 consecutive urine samples collected in the early morning, being considered positive when at least two determinations were above 15 mg/g creatinine.

The prevalence of MA (+) was 12,5% (63 out of the 502 EH). These patients exhibit higher SBP, triglycerides, serum uric acid and creatinine than those MA (-). Forty-five EH MA(+) entered in the double blind randomized comparative study. MA was measured in 24h urine samples collected at the beguinning and at the end of the follow-up. Treatment with R reduced significantly both BP (baseline: 152±14/90±7; 3 month: 142±16/85±9 mmHg,p<0.005) and MA (baseline: 88±64; 3 month: 60±71 mg/24h, p<0.002). EH treated with A had similar reduction of BP but the decrease of MA (baseline:55±29; 3 month:47±46 mg/24h) was not statistically significant.

The prevalence of MA among newly diagnosed, non-treated essential hypertensives was 12.5%. Treatment with ramipril or atenolol induced a significant reduction of BP but only ramipril achieved a significant reduction of MA.

microalbuminuria, newly diagnosed patients, treatment of hypertension