P-288: The effect of hormone replacement therapy on arterial structure and renal function in hypertensive postmenopausal women

Abstract

Objective: The aim of the study was to evaluate influence hormone replacement therapy (HRT) on aortic pulse wave velocity (PWV) effective renal plasma flow (ERPF), renovascular resistance (RVR) in hypertensive women.

Design and Methods: 40 hypertensive women (mean age 50,4 ± 5,8 years) were randomized to receive 6 month of therapy HRT (17-β-Estradiol and Noretisterone Acetate) or without HRT. All women had antihypertensive treatment and were normotensive during the study. Carotid-femoral PWV was measured by means of automatic device Complior Colson. Effective plasma flow was measured as clearance of J-125 hippurate. RVR was calculated from mean arterial blood pressure (MAP) and ERPF.

Results: There were no differences in baseline blood pressure and PWV, ERPF, RVR between two groups. Blood pressure decreased not significantly after 6 months of HRT treatment in studied group. Table summarizes the results (mean and ± SD). Effect of HRT on blood pressure, PWV, ERPF, RVR was as in table.

	HRT		Control
	Baseline	After 6 months	Baseline	After 6 months
SBP [mmHg]	138±10	131±8	137±12	135±13
DBP [mmHg]	88±9	82±6	86±10	84±11
PWV [m/s]	10,31±1,31	8,89±1,18	10,88±1,84	10,4±1,4
ERPF [ml/min]	409±100,5	498±110,5	405±99,5	410±112,5
RVR [U]	0,17±0,04	0,12±0,02	0,17±0,04	0,16±0,04

Positive correlation was found between PWV, ERPF and RVR.

Conclusions:

1. Short-term combined HRT improves arterial structure and function in hypertensive postmenopausal women.

2. Short-term combined HRT improves renal parameters (ERPF, RVR) in hypertensive postmenopausal women.

3. HRT has not influence on blood pressure in hypertensive postmenopausal women during 6 months treatment.

arterial compliance, hypertension, hormonal replacement therapy