P-401: Non-invasive hemomodynamic evaluation of left ventricular function by arterial waveform analysis in hypertension

Abstract

Non-Invasive Hemodynamic

Since arterial blood presure waveform results from the complex interaction between heart hemodynamic and the physical properties of arterial tree, it has considerable importance the routine evaluation of such factors in HT. In one year study, we included routine: LVET, Arterial end-systolic elastance (Ea), LV Isovolumetric Phase indices (dP/dT max, dP/dT40 and Contractility), Ejection Phase Indices (SV, SV index, CO, CI) and Pressure-Volume relation (LVSW, LVSW index, Cardiac Work and Cardiac Work Index), derivated from Arterial Waveform Analysis (Dyna Pulse 200). This study, at rest, isometric hand grip & 15 min later, was recorded in 287 untreated HT subjects (Female n=150, Male n=137, age 53±14 yrs; BP 144.6±28/ 79.5 ±13 mmHg; PP: 66±117 and HR 70±12 b/m). RESULTS: LVET 323±47msc; Ea 1.78±0.72 mmHg/ml; dP/dT max 1.218±367 mmHg/s, dP/dT40 30.45±9 s-1; Contractility 15.5±4.5 1/s; SV 75±20 ml/b, SV index 42±11 ml/b/m2; CO 5.1±1 l/min, CI 2.8±0.5 l/min/m2; LVSW 74±22 mmHg.ml/b, LVSW index 41±12 mmHg.ml/b/m2; Cardiac Work 67±18 J/min and Cardiac Work Index 37±9 J/min/m2. Linear correlation: SBP was significantly correlated with dP/dTmax (r=- 0.67, p .000) dP/dT 40 (r=0.67, p .000) and Ea (r=0.40, p .000). DBP and MBP showed good corelation with LVSW (0.47, p.000), LVSW index (r= 0.42, p.000), Cardiac work (r=0.60, p.000), CW index (r=0.61, p.000). CONCLUSION: This study document that HT imposes harder hemodynamics to heart function and that these parameters should be routinely evaluated.

Non-invasive hemodynamics, LV dP/dt, LVET