P-142: Association of endothelial no synthase gene polymorphism with serum UA levels

Abstract

Hyperuricemia has been shown to be an independent risk factor for cardiovascular death. In the present study, the genetic predisposition for serum level of uric acid was investigated. Middle aged 637 subjects free from any medications and without any history of cardiovascular diseases were enrolled from the cohort in Ehime. Gene polymorphism of angiotensin converting enzyme (ACE) insertion/deletion and endothelial nitric oxide synthase (eNOS) Glu298Asp variant were determined in each subject. Serum uric acid (UA) was not significantly different among ACE genotypes. While serum UA was significantly different among eNOS genotypes.

Multiple regression analysis further showed that eNOS gene polymorphism is associated with serum UA independently of sex, body mass index, serum triglyceride, and systolic blood pressure.

These findings indicate that eNOS genotype would be involved for serum level of UA. (See Table)

ACE		II	ID	DD	p
	n	262	279	96	(II vs ID vs DD)
	UA	5.6±1.3	5.7±1.3	5.6±1.1	0.77
eNOS		GG	GA	AA	p
	n	534	94	9	(GG vs GA vs AA)
	UA	5.7±1.3	5.4±1.2	4.8±1.0	0.02

serum UA, endothelial NO synthase, gene polymorphisms