P-514: Polymorphism of peroxisome proliferator activated receptor delta in the patients with metabolic syndrome

Abstract

Peroxisome proliferator activated receptors (PPARs) play an important role in lipid metabolism and glucose homeostasis, however, PPAR delta is little known. Recent study showed that the variation at the PPAR delta locus associated with plasma LDL concentration in healthy men. The present study examines the polymorphism of PPAR delta in Chinese patients with metabolic syndrome (MS), type 2 diabetes mellitus (T2DM), and essential hypertension (EH). Polymerase chain reaction restricted fragments length polymorphism was used to study distribution of the PPAR delta 294T/C in exon 4 in 144 MS, 102 EH and 68 T2DM. Fasting insulin(FINS),fasting blood glucose(FBG), uric acid(UA), plasma lipids and doppler echocardiography for left ventricular mass index were examined. Blood pressure and BMI were significantly higher in MS than T2DM. In MS, the distribution frequencies of the TT, TC and CC genotype were 67.5%, 26.9% and 5.6%, respectively; In EH, it was 68.1%, 27.1% and 4.6%; In T2DM, it was 69.5%, 26.3% and 4.2%. There was no difference among three group. In MS, subjects with CC genotype had significantly higher levels of total cholesterol and LDL compared with subjects with TT or TC genotype( TC:6.88 ± 2.51 vs 5.02 ± 1.05 or 5.10 ± 0.93 mmol/l, p<0.01; LDL: 4.48±2.0 vs 2.89±0.79 or 2.86 ± 0.97mmol/l, p<0.01. In MS, subjects with CC genotype had significantly higher left ventricle mass(LVM) and left ventricle mass index (LVMI) compared with subjects with TT genotype (LVM:123±23 vs 87±17 g, P<0.05; LVMI:48 ± 9 vs 26 ± 5, p<0.01). No difference in levels of plasma lipid and left ventricular remodeling was found in EH and T2DM subjects with different genotype of PPAR delta. It concluded that PPAR delta plays a role in lipid metabolism. PPAR delta may effect on left ventricle remodeling through regulation of lipid metabolism in MS.

Am J Hypertens (2004) 17, 220A–221A; doi: 10.1016/j.amjhyper.2004.03.588

Metabolic Syndrome, PPAR Delta, Cardiac Hypertrophy