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Effect of Surgical Treatment on Hypertension in Cushing’s Syndrome

Francesco Fallo

1

Division of Endocrinology, Institute of Semiiotica Medica, University of Padova

,

Italy

Address correspondence and reprint requests to F. Fallo, MD,

Division of Endocrinology, Institute of Semeiotica Medica, University of Padova

,

Via Ospedale 105, 35128 Padova

,

Italy

.

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Francesco Fallo

Nicoletta Sonino

1

Division of Endocrinology, Institute of Semiiotica Medica, University of Padova

,

Italy

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Nicoletta Sonino

Luisa Barzon

1

Division of Endocrinology, Institute of Semiiotica Medica, University of Padova

,

Italy

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Luisa Barzon

Matteo Pistorello

1

Division of Endocrinology, Institute of Semiiotica Medica, University of Padova

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Italy

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Matteo Pistorello

Uberto Pagotto

1

Division of Endocrinology, Institute of Semiiotica Medica, University of Padova

,

Italy

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Uberto Pagotto

Agostino Paoletta

1

Division of Endocrinology, Institute of Semiiotica Medica, University of Padova

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Italy

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Agostino Paoletta

Marco Boscaro

1

Division of Endocrinology, Institute of Semiiotica Medica, University of Padova

,

Italy

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Marco Boscaro

American Journal of Hypertension, Volume 9, Issue 1, 1 January 1996, Pages 77–80, https://doi.org/10.1016/0895-7061(95)00299-5

Published:

01 January 1996

Article history

Received:

22 May 1995

Accepted:

18 July 1995

Abstract

The effect of a surgical cure of hypercortisolism on hypertension in 54 patients with Cushing’s syndrome was assessed. The correlation between preoperative duration of hypertension and posttreatment blood pressure was significant (P < .01). Restoration of normal cortisol was associated with blood pressure normalization in 39 out of 54 cases. Duration of hypertension of patients with normalized blood pressure was significantly shorter than that of patients with persistent hypertension post-operatively (P < .0001). Duration of hypertension, ie, long-lasting exposure to increased cortisol, appears to be the determinant of persistent hypertension following successful surgery in Cushing’s syndrome.

Am J Hypertens 1996;9:77–80

Hypertension, surgery, Cushing’s syndrome, hypercortisolemia

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© 1996 by the American Journal of Hypertension, Ltd.

American Journal of Hypertension, Ltd.

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