# Instructions for Authors

Scope

The American Journal of Hypertension is a monthly, peer-reviewed journal that provides a forum for scientific inquiry of the highest standards in the field of hypertension and related cardiovascular disease. The journal publishes high-quality original research and review articles on basic sciences, molecular biology, clinical and experimental hypertension, cardiology, epidemiology, pediatric hypertension, endocrinology, neurophysiology, and nephrology.

The journal is well-regarded, with an Impact Factor of 2.852 and a current ranking of 25 of 60 by Impact Factor in the Peripheral Vascular Disease category of the 2014 JCR Science Edition.

## PREPARATION OF MANUSCRIPTS

Content Types
(1) Original Contributions
Original Contributions are manuscripts containing substantial novel research.
Word Limit: 3,000 words maximum excluding abstract, references, tables, and figures
Abstract: 250 words maximum
References: 40 maximum
Figures/Tables: 4 figures, 4 tables maximum

(2) Brief Communications
Brief Communications are manuscripts containing concise and timely information.
Word Limit: 2,000 words maximum, excluding abstract, references, tables, and figures
Abstract: 250 words maximum
References: 20 maximum
Figures/Tables: 1 maximum

(3) Review [generally by invitation of Editors]
Review articles are comprehensive analyses of specific topics in hypertension that are usually solicited by the Editors. Proposals for State of the Art Review articles may be submitted; however, in this case authors should only send an outline of the proposed paper for initial consideration. Both solicited and unsolicited review articles will undergo peer review prior to acceptance.
Word Limit: 4,000 words maximum, excluding abstract, references, tables, and figures
Abstract: 250 words maximum
References: 100 maximum
Figures/Tables: no maximum

(4) Case Reports
Case Reports are manuscripts containing a substantial novel finding.
Word Limit: 1,500 words maximum excluding abstract, references, tables, and figures
Abstract: no abstract for this manuscript type
References: 20 maximum
Figures/Tables: 3 maximum

(5) Commentaries [only by invitation of Editors]
Commentaries typically provide additional insight to the readers based upon the reviewer's perspective of the paper and of the field in general.
Word Limit: 1500 words excluding references, tables, and figures
Abstract: none required
References: 20 maximum
Figures/Tables: 1 maximum

(6) Opinion [generally by invitation of Editors]
Opinion pieces typically provide insight to the readers about specific topics in hypertension and of the field in general. Both solicited and unsolicited manuscripts will undergo peer review prior to acceptance.
Word Limit: 1500 words excluding references, tables, and figures
Abstract: none required
References: 20 maximum
Figures/Tables: 1 maximum

(7) Editorial [only by invitation of Editors]
Word Limit: 800-1,600 words excluding references, tables, and figures
References: 10 maximum
Figures/Tables: 1 maximum

(8) Letters to the Editor
Letters to the Editor typically should address issues concerning recently published information in American Journal of Hypertension and should be received within 6 weeks of the publication of the paper it addresses. A Letter to the Editor must reference the original source, and a Response to a Letter must reference the Letter to the Editor in the first few paragraphs. Letters to the Editor can use an arbitrary title, but a Response must cite the title of the Letter: e.g. Response to [title of Letter].
Word Limit: 500 words excluding references, tables, and figures
Abstract: no abstract for this manuscript type
References: 4 maximum
Figures/Tables: 1 maximum

(9) Book Reviews [only by invitation of Editors]
Review of current relevant published books.
Word Limit: 700 words maximum, excluding references
References: N/A
Figures/Tables: 1 maximum

## FORMAT OF MANUSCRIPTS

General format : Manuscripts, including abstracts and references, must be typed in English and double-spaced. All manuscript pages must be numbered. (See Journal Style.)

Title page: This should include
(a) the complete manuscript title of no more than 150 characters;
(b) the running head of no more than 50 characters;
(c) word counts for your abstract and text (the text word count does not include the abstract, references, tables, and figures) in the upper right corner of the title page;

(d) the number of references and the number of figures and tables below the word counts;
(e) all authors' names (listed as first and middle initials followed by last name) and affiliations;
(f) the name, address, telephone, and fax numbers and email address of the corresponding author;
(g) a conflict of interest statement (see DISCLOSURE); and
(h) keywords.

Text : For contributions requiring abstracts, the lengths are defined in the respective sections of Preparation of Manuscripts. Abstracts for Brief Communications and Original Contributions require the headings BACKGROUND, METHODS, RESULTS, AND CONCLUSIONS. For contributions that do not require an abstract, introductory paragraphs may contain references to cited work. Manuscripts should nominally be organized under the following main headings: Introduction, Methods, Results, Discussion, and Disclosure.

Originality : A submitted manuscript must be an original contribution not previously published (except as an abstract), must not be under consideration for publication elsewhere, and, if accepted, must not be reproduced elsewhere without the consent of the American Journal of Hypertension, Ltd. Although the editors, editorial board, and referees make every effort to ensure the validity of published manuscripts, the final responsibility rests with the authors, not with American Journal of Hypertension, its editors, the American Journal of Hypertension, Ltd. or Oxford University Press.

Informed consent and ethics : When reporting experiments on human subjects, indicate whether the procedures were in accordance with the ethical standards of the responsible committee on human experimentation (institutional or regional) or with the Helsinki Declaration of 1975 (as revised in 1983). Include Institutional Review Board or Animal Care and Use Committee approvals.

Clinical Trials Registry : Registration in a public trials registry is required for publication in American Journal of Hypertension. A clinical trial is defined as any research project that prospectively assigns human subjects to intervention or comparison groups to study the cause-and-effect relationship between a medical intervention and a health outcome. Studies designed for other purposes, including exploring pharmacokinetics or safety and tolerability (e.g., phase 1 trials) are exempt.

Registration must be with a registry that meets the following criteria: (1) accessible to the public at no charge; (2) searchable by electronic methods; (3) open to all prospective registrants free of charge or at minimal cost; (4) validates registered information; (5) identifies trials with a unique number; and (6) includes information on the investigator(s), research question or hypothesis, methodology, intervention and comparisons, eligibility criteria, primary and secondary outcomes measured, date of registration, anticipated or actual start date, anticipated or actual date of last follow-up, target number of subjects, status (anticipated, ongoing, or closed), and funding source(s).

Examples of registries that meet these criteria include (1) The registry sponsored by the United States National Library of Medicine ( http://www.clinicaltrials.gov ); (2) The International Standard Randomised Controlled Trial Number Registry ( http://www.controlled-trials.com ); and (3) European Clinical Trials Database ( https://eudract.ema.europa.eu/).

Abbreviations : Abbreviations should be defined at the first mention in the text and in each table and figure. For a list of standard abbreviations, please consult the Council of Biology Editors Style Guide (available from the Council of Science Editors, 9650 Rockville Pike, Bethesda, MD 20814) or other standard sources. Write out the full term for each abbreviation at its first use unless it is a standard unit of measure.

Style : The American Medical Association Manual of Style (9th edition), Stedman's Medical Dictionary (28th edition) and Merriam Webster's Collegiate Dictionary (11th edition) should be used as standard references. Refer to drugs and therapeutic agents by their accepted generic or chemical name, and do not abbreviate them (a proprietary name may be given only with the first use of the generic name). Code names should be used only when a generic name is not yet available (the chemical name and a figure giving the chemical structure of the drug are required). Copyright or trade names of drugs should be capitalized and placed in parentheses after the name of the drug. Names and locations (city and state in United States; city and country outside United States) of manufacturers of drugs, supplies, or equipment cited in a manuscript are required to comply with trademark law and should be provided in parentheses. Quantitative data may be reported in the units used in the original measurement (e.g., mg/dl for serum glucose, calcium, phosphorus, creatinine, BUN). SI units are preferred for body weight, mass (weight), volume, and temperature.

Disclosure : All authors are responsible for recognizing and disclosing any conflict of interest that could be perceived to bias their work, making known all financial support and any other personal connections. This includes, but is not limited to: funding, such as salaries, equipment, supplies, reimbursement for attending symposia, etc, from organizations that may gain or lose financially through the publication of the paper; personal financial interests, such as stocks and shares in companies that may gain or lose financially from publication, consultation fees or forms of remuneration from organizations that may gain or lose financially, or patent and patent applications whose value may be affected; and employment, whether recent, present, or anticipated, by an organization that may gain or lose from publication of the paper. Such relationships will be reviewed, and further clarification may be requested if deemed necessary by the editors or reviewers. This information should be included in the title page and in the article under the heading "Disclosure." This section should appear at the end of the main text, before the references. If you have no conflict of interest to declare, please state so in the "Disclosure" section.

Acknowledgments : This should include sources of support, including federal and industry support.

References : References should be typed double-spaced. References are to be numbered in the order of citation within the article. Citations in the main text should appear as superscript Arabic numerals. All authors must be listed. Abstracts must be identified as such. Periodical abbreviations should follow those used by Index Medicus. Personal communications and unpublished data should be included within the text of the manuscript, not as references. Individual references should be formatted in Vancouver style as follows:

Journal articles: Lender D, Arauz-Pacheco C, Breen L, Mora-Mora P, Ramirez LC, Raskin P. A double-blind comparison of the effects of amlodipine and enalapril on insulin sensitivity in hypertensive patients. Am J Hypertens 1999; 12:298-303.

Books: Cheriyan J, McEniery C, Wilkinson IB. Hypertension. Oxford University Press, New York, 2010, pp 39-41.

Articles in books: Landzberg M: Clinical assessment of the patient with suspected PAH and the role of cardiac catherization. In Gatzoulis M (ed), Pulmonary Arterial Hypertension. New York, Oxford University Press, 2012, pp. 357-359.
Accessing databases according to AMA:
“In citing data from an online database, include the following elements, if applicable, in the order shown:
Author(s). Title of the database [database online]. Publisher’s location (city, state, or, for Canada, city, province, country, or, all others, city, country): publisher’s name; year of publication and/or last update. URL [provide URL and verify that the link still works as close as possible to publication]. Accessed [date].

Additional notes that might be helpful or of interest to the reader (eg, date the site was updated or modified) may also be included.
1. PDQ: NCI’s Comprehensive Cancer Database. Bethesda, MD: National Cancer Institute; 1996. http://www.cancer.gov/cancerinfo/pdq/cancerdatabase. Updated December 18, 2001. Accessed April 29, 2004.
2. Genew, HUGO Gene Nomenclature Committee (HGNC). Human Gene Nomenclature Database Search Engine. http://www.gene.ucl.ac.uk/cgi-bin/nomenclature/searchgenes.pl. Accessed February 27, 2004.
3. Online Mendelian Inheritance in Man, OMIM. Baltimore, MD: Johns Hopkins University Press; 2000. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=OMIM. Accessed December 6, 2005.”

Unpublished data citation according to AMA
i. “Material Accepted for Publication but Not Yet Published.
Formats suggested for both journal articles and books, accepted for publication but not yet published, are shown below:
Examples:
6. Carrau RL, Khidr A, Crawley JA, Hillson EM, Davis JK, Pashos CL. The impact of laryngopharyngeal reflux on patient-reported quality of life. Laryngoscope. In press.
7. Ofri D. Incidental Findings: Lessons From My Patients in the Art of Medicine. Boston, MA: Beacon Press. In press."

When submitting an invited Commentary or Editorial and citing an unpublished article that will appear in the same issue, authors should make a note in the manuscript during submission and/or proof corrections that the reference will be in the current issue. This will alert Production to update the publication details for that reference.

ii. "Material Submitted for Publication but Not Yet Accepted.
In the list of references, do not include material that has been submitted for publication but has not yet been accepted. This material, with its date, should be noted in the text as “unpublished data,” as follows:
Examples:
These findings have recently been corroborated (H. E. Marman, MD, unpublished data, January 2005).
Similar findings have been noted by Roberts6 and H. E. Marman, MD (unpublished data, 2005).
Numerous studies12-20 (also H. E. Marman, MD, unpublished data, 2005) have described similar findings.”

Tables
Each table should be double-spaced on a separate sheet and numbered consecutively in the order of first citation in the text. Minimize empty space. Supply a brief title of no more than 15 words for each, but place explanatory matter in the footnotes (not in the heading). Do not use internal horizontal and vertical lines. Tables should be supplied in separate “table” files in Editorial Manager.

Figures
Figures should be labeled sequentially, numbered, and cited in the text. If a table, figure, or any other previously published material is included, the authors must obtain written permission to reproduce the material in both print and electronic formats from the copyright owner and submit it with the manuscript. The original source should be cited. Figure legends: Legends should be brief and specific, and should appear on a separate manuscript page after the Reference section. All abbreviations used in an illustration should be expanded in the legend.

Additional clarification on tables and figures can be found here .

Language Editing :
Language editing, if your first language is not English, to ensure that the academic content of your paper is fully understood by journal editors and reviewers is optional. Language editing does not guarantee that your manuscript will be accepted for publication. For further information on this service, please click here . Several specialist language editing companies offer similar services and you can also use any of these. Authors are liable for all costs associated with such services.

## GUIDELINES FOR FIGURES AND ARTWORK

Please be aware that the figure requirements for initial online submission (peer review) and for reproduction in the journal are now the same. Authors should now supply final high-resolution .tif or .eps files for reproduction in the journal at the time of submission. Figures and images should be supplied in separate files in Editorial Manager indicated as "bw figure" or "color figure". Figure legends should be typed separately from the figures and placed in the main text document. Please submit production quality artwork with your initial online submission. If you have followed the guidelines, we will not require the artwork to be resubmitted following the peer-review process.

Figures in Print[color charges may apply]
Minimum resolutions:
Halftone images, 300 dpi (dots per inch)
Color images, 300 dpi saved as CMYK
Images containing text, 400 dpi
Line art, 1000 dpi

Sizes :
Figure width - single image
86 mm (should be able to fit into a single column of the printed journal)
Figure width - multi-part image
178 mm (should be able to fit into a double column of the printed journal)

Text size :
8 point (should be readable after reduction—avoid large type or thick lines). Line width between 0.5 and 1 point.

Color on the web
For FREE color figures on the web (only available in the HTML (full text) version of manuscripts), authors should supply separate files in the following format. These files should be submitted as supplementary information and indicated as such in the submission letter.

For single images :
Width
500 pixels (authors should select "constrain proportions," or equivalent instructions, to allow the application to set the correct proportions automatically)

Resolution :
125 dpi (dots per inch)

Format :
JPEG for photographs
GIF for line drawings or charts

File naming :
Please save image with .jpg or .gif extension to ensure it can be read by all platforms and graphics packages.

For multi-part images :

Width :
900 pixels (authors should select "constrain proportions," or equivalent instructions, to allow the application to set the correct height automatically)

Resolution :
125 dpi (dots per inch)

Format :
JPEG for photographs
GIF for line drawings or charts

File naming :
Please save image with .jpg or .gif extension to ensure it can be read by all platforms and graphics packages.

In order to reproduce any third party material, including figures or tables, in an article authors must obtain permission from the copyright holder and be compliant with any requirements the copyright holder may have pertaining to this reuse.

When seeking to reproduce any kind of third party material authors should request the following:

(i) non-exclusive rights to reproduce the material in the specified article and journal;
(ii) electronic rights, preferably for use in any form or medium;
(iii) the right to use the material for the life of the work; and
(iv) world-wide English-language rights.

Further guidelines on clearing permissions can be found at: http://www.oxfordjournals.org/access_purchase/permissions_guidelines.doc .

Authors should also include a statement indicating that permission has been obtained in the relevant legend/footnote and provide the Editorial Office with copies of any relevant paperwork.

A template permissions request letter can be found at the end of the above document.

## JOURNAL STYLE

Papers should be prepared as follows:

1. See the artwork guidelines for information on labeling of figures
2. Do not make rules thinner than 1 pt (0.36mm)
3. Use a coarse hatching pattern rather than shading for tints in graphs
4. Color should be distinct when used as an identifying tool
5. Commas, not spaces, should be used to separate thousands
6. Abbreviations should be preceded by the words for which they stand in the first instance of use
7. Text, including references, should be double-spaced with a 1 inch margin
8. Text should be submitted with line numbers (In MSWord, go to File, Page Setup, Layout, Line Numbers, and check Add Line Numbering)
9. At first mention of a manufacturer, the city (state if USA) and country should be provided

File formats : File formats are provided on the online forms. Please use a common word-processing package (such as Microsoft Word*) for the text. Tables should be provided in a separate file.

*Microsoft Office 2007 saves files in an XML format by default (file extensions .docx, .pptx and xlsx). Files saved in this format cannot be accepted for publication.
Save Word documents using the file extension .doc.
Select the Office Button in the upper left corner of the Word 2007 Window and choose "Save As"
Select "Word 97-2003 Document."
Enter a file name and select "Save."
These instructions also apply for the new versions of Excel and PowerPoint.

Equations in Word must be created using Equation Editor 3.0
Equations created using the new equation editor in Word 2007 and saved as a "Word 97-2003 Document" (.doc) are converted to graphics and can no longer be edited. To insert or change an equation with the previous equation editor: Select "Object" on the "Text" section of the "Insert" tab.
In the drop-down menu - select "Equation Editor 3.0."
Do not use the "Equation" button in the "Symbols" section of the "Insert" tab.

## SUPPLEMENTARY INFORMATION

Supplementary information is peer-reviewed material directly relevant to the conclusion of an article that cannot be included in the printed version owing to space or format constraints. It is posted on the journal's web site and linked to the article when the article is published and may include data files, graphics, movies, or extensive tables. The printed article must be complete and self-explanatory without the supplementary information. Supplementary information must be supplied to the editorial office in its final form for peer review. On acceptance, the final version of the peer-reviewed supplementary information should be submitted with the accepted paper. To ensure that the contents of the supplementary information files can be viewed by the editor(s), referees, and readers, please also submit a 'read-me' file containing brief instructions on how to use the file.

Supplying supplementary information files
Authors should ensure that supplementary information is supplied in its FINAL format because it is not copy edited and will appear online exactly as originally submitted. It cannot be altered, nor new supplementary information added, after the paper has been accepted for publication. Please supply the supplementary information through the electronic manuscript submission and tracking system, in an acceptable file format (see below). Authors should include a text summary (no more than 50 words) to describe the contents of each file; identify the types of files (file formats) submitted, and include the text 'Supplementary information is available at http://www.oup.com/ajh' at the end of the body of text and before the references.

Accepted file formats : Quick Time files (.mov), graphical image files (.gif), HTML files (.html), MPEG movie files (.mpg), JPEG image files (.jpg), sound files (.wav), plain ASCII text (.txt), Acrobat files (.pdf), MS Word documents (.doc), Postscript files (.ps), MS Excel spreadsheet documents (.xls), and PowerPoint files (.ppt). We cannot accept TeX and LaTeX. File sizes must be as small as possible, so that they can be downloaded quickly. Images should not exceed 640 x 480 pixels, but we would recommend 480 x 360 pixels as the maximum frame size for movies. We would also recommend a frame rate of 15 frames per second. If applicable to the presentation of the supplementary information, use a 256-color palette. Please consider the use of lower specification for all of these points if the supplementary information can still be represented clearly. Our recommended maximum data rate is 150 KB/s.

The number of files should be limited to eight, and the total file size should not exceed 8 MB. Individual files should not exceed 1 MB. Please seek advice from the editorial office before sending files larger than our maximum size to avoid delays in publication. Further questions about the submission or preparation of supplementary information should be directed to the editorial office.

## SUBMISSION AND PUBLICATION

Submission of papers
Please visit the online submission page http://www.editorialmanager.com/ajh/ to submit a manuscript. A fee of $50 will be charged for each paper submitted. The submission fee may be paid by credit card through PayPal, or by check or money order. Please make checks payable to "American Journal of Hypertension" and mail to American Journal of Hypertension, P.O. Box 207, Vernon NJ 07462. This fee does not apply to invited authors. Crossref Funding Data Registry In order to meet your funding requirements authors are required to name their funding sources, or state if there are none, during the submission process. For further information on this process or to find out more about the CHORUS initiative please click here . Back to Top ## STATISTICAL GUIDELINES Authors are also encouraged to read information about Statistical Guidelines before submitting papers. If you are ready to submit an article, please click on Online Submission . Back to Top ## CONTACT INFORMATION Editorial : For all business regarding manuscripts and peer review, please contact: Managing Editor : Yvonne P. Raiford at email edit@ajhypertens.org. Tel: 973-764-1583 Fax: 973-764-1650 Business matters All business correspondence and enquiries should be addressed to: Journals Customer Service Department, Oxford University Press 2001 Evans Road, Cary, NC 27513, USA. Tel: + 1 919-677-0977 + 1-800-852-7323 (toll-free in USA/Canada) Fax: + 1 919-677-1714 Back to Top ## OPEN ACCESS & SELF ARCHIVING American Journal of Hypertension authors have the option to publish their paper under the Oxford Open initiative ; whereby, for a charge, your paper will be made freely available online immediately upon publication. After your manuscript is accepted the corresponding author will be required to sign a mandatory license to publish agreement. As part of the licensing process you will be asked to indicate whether or not you wish to pay for open access. If you do not select the open access option, your paper will be published with standard subscription-based access and you will not be charged. Oxford Open articles are published under Creative Commons licenses. RCUK/Wellcome Trust funded authors publishing in American Journal of Hypertension may use the Creative Common Attribution licence (CC BY) for their articles. All other authors may choose from the following Creative Commons licenses: • Creative Commons Attribution Non-Commercial license (CC BY-NC) • Creative Commons Attribution Non-Commercial No Derivatives license (CC BY-NC-ND) Please click here for more information about the Creative Commons licenses. You can pay Open Access charges using our Author Services site. This will enable you to pay online with a credit/debit card, or request an invoice by email or post. The applicable open access charges vary according to which Creative Commons license you select. The open access charges are as follows. Charges for CC BY • Regular charge: £2250/$3650/ €2950• List B Developing country charge* - £1125 / $1825 / €1475 • List A Developing country charge* - £0 /$0 / €0

Charges for CC BY-NC/CC BY-NC-ND:
• Regular charge: £2000/ $3200 / €2600 • Reduced Rate Developing country charge* - £1000 /$1600 / €1300
• Free Developing country charge* - £0 /\$0 / €0

Please note that these charges are in addition to any color charges that may apply.

Orders from the UK will be subject to the current UK VAT charge. For orders from the rest of the European Union, OUP will assume that the service is provided for business purposes. Please provide a VAT number for yourself or your institution, and ensure you account for your own local VAT correctly.