Topical 5% alpha lipoic acid cream in the treatment of cutaneous rhytids

Abstract

Background: Topical 5% alpha lipoic acid cream has been reported to improve the appearance of facial lines associated with photoaging.

Objective: The purpose of this study was to determine the efficacy of 5% alpha lipoic acid cream in the treatment of photodamaged skin.

Methods: Alpha lipoic acid was placed in a lecithin-based cream at a concentration of 5% in combination with the penetration enhancer dimethylaminoethanol and applied to subjects' faces twice a day for 12 weeks.

Results: Topical alpha lipoic acid cream, at a concentration of 5%, resulted in the reduction of facial lines, and almost complete resolution of fine lines in the periorbital region and upper lip was noted in most patients. Also noted was a 50% reduction in depth of medium vertical lines on the upper lip, a significant reduction in pore size, and overall improvement in skin color and texture in all patients. There were no instances of irritation or peeling.

Conclusions: Topical 5% alpha lipoic acid cream is effective in the treatment of photo-damaged skin with no apparent adverse side effects.