https://orcid.org/0000-0003-2445-8238
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Fumika Yokoyama, Satoshi Tsuyama, Satoshi Ishizuka, A cholic acid–supplemented diet suppresses very-low-density lipoprotein secretion in rats in the presence of insulin, Bioscience, Biotechnology, and Biochemistry, 2025;, zbaf041, https://doi.org/10.1093/bbb/zbaf041
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Abstract
We investigated whether dietary supplementation with cholic acid (CA) suppressed hepatic very-low-density lipoprotein (VLDL) secretion in rats. Dietary CA supplementation suppressed VLDL secretion in vivo in the presence of insulin. These results suggest that enterohepatic 12-hydroxylated bile acids further enhance insulin-induced suppression of hepatic VLDL secretion, which contributes to hepatic lipid accumulation.
© The Author(s) 2025. Published by Oxford University Press on behalf of Japan Society for Bioscience, Biotechnology, and Agrochemistry.
This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model)
Subject
Food and Nutrition Science
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