The Formation of Argpyrimidine in Glyceraldehyde-Related Glycation

Abstract

Three major glyceraldehyde-related advanced glycation end products (AGEs) were formed from a mixture of N^α-acetyllysine, N^α-acetylarginine, and glyceraldehyde. Two of the compounds were MG-H1 and GLAP, as previously reported, and the other compound was identified as N^α-acetyl-N^δ-(5-hydroxy-4,6-dimethyl-pyrimidin-2-yl)-ornithine, argpyrimidine (APN). APN is a modification product of arginine residue, but it did not form from glyceraldehyde with arginine residue. The coexistence of lysine residue was necessary to APN formation.

glyceraldehyde, argpyrimidine, methylglyoxal, glycation, Maillard reaction