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Abstract

We examined the effect of perfluorooctanoic acid (PFOA) on adipose cells using 3T3-L1 adipocytes and found that PFOA increased adipocyte differentiation, triglyceride accumulation, and the mRNA level of factors related to adipocyte differentiation. In addition, PFOA bound to peroxisome proliferator-activated receptor γ (PPAR γ). These results suggest that PFOA promotes adipocyte differentiation as a PPAR γ ligand.

perfluorooctanoic acid, peroxisome proliferator-activated receptor γ, 3T3-L1 adipocyte, adipocyte differentiation
© 2015 Japan Society for Bioscience, Biotechnology, and Agrochemistry
This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model)
Subject
Biochemistry and Molecular Biology
Issue Section:
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