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Abstract

Zearalenones are mycotoxins with estrogenic activity consisting of a resorcinol moiety fused to a 14-membered macrocyclic lactone and are produced by various Fusarium species. We found that Clonostachys rosea IFO 7063 was effectively capable of converting zearalenone (1) to cleavage product (2), 1-(3,5-dihydroxyphenyl)-10′-hydroxy-1′E-undecene-6′-one. Moreover, cleavage product 2 did not show potent estrogenic activity like that of 1 and 17β-estradiol in the human breast cancer MCF-7 cell proliferation assay.

biotransformation, zearalenone, mycotoxins, microorganisms, detoxification

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© 2002 by Japan Society for Bioscience, Biotechnology, and Agrochemistry
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