TY  - JOUR
T1  - minimac2: faster genotype imputation
AU  - Fuchsberger, Christian
AU  - Abecasis, Gonçalo R.
AU  - Hinds, David A.
Y1  - 2015/03/01
N1  - 10.1093/bioinformatics/btu704
JO  - Bioinformatics
SP  - 782
EP  - 784
VL  - 31
IS  - 5
N2  - Summary: Genotype imputation is a key step in the analysis of genome-wide association studies. Upcoming very large reference panels, such as those from The 1000 Genomes Project and the Haplotype Consortium, will improve imputation quality of rare and less common variants, but will also increase the computational burden. Here, we demonstrate how the application of software engineering techniques can help to keep imputation broadly accessible. Overall, these improvements speed up imputation by an order of magnitude compared with our previous implementation.Availability and implementation: minimac2, including source code, documentation, and examples is available at http://genome.sph.umich.edu/wiki/Minimac2Contact:cfuchsb@umich.edu, goncalo@umich.edu
SN  - 1367-4803
M3  - doi: 10.1093/bioinformatics/btu704
UR  - http://dx.doi.org/10.1093/bioinformatics/btu704
ER  -