Assisted reproductive technologies in the common marmoset: an integral species for developing nonhuman primate models of human diseases
This review presents a summary of assisted reproductive technologies utilized to generate in vitro produced embryos in the common marmoset and describes prospects for genomic editing and transgenesis to create nonhuman primate models of human disease.
Peptide targeting of connexins protects bovine blastocysts against vitrification/warming stress by preventing the opening of hemichannels that function as a leakage pathway.
Female Reproductive Tract
Decreased epithelial progesterone receptor A at the window of receptivity is required for preparation of the endometrium for embryo attachment
Expression of PGRA at the window of receptivity transcriptionally represses LIF signaling and aberrantly regulates hedgehog and solute signaling rendering the uterus unreceptive to the implanting embryo.
Defining age- and lactocrine-sensitive elements of the neonatal porcine uterine microRNA–mRNA interactome,
Comprehensive microRNA–mRNA analyses identified novel age- and lactocrine-sensitive porcine uterine microRNAs, microRNA–mRNA interactions, and biological processes associated with porcine neonatal uterine development.
Embryonic poly(A)-binding protein is required at the preantral stage of mouse folliculogenesis for oocyte–somatic communication
EPAB is an oocyte-specific translational regulator that has a precise role at the preantral stage of follicle development for establishing communication between the oocyte and somatic cells.
Redistribution of soluble N-ethylmaleimide-sensitive-factor attachment protein receptors in mouse sperm membranes prior to the acrosome reaction
Although the sperm plasma membrane SNARE protein syntaxin 2 moves laterally, trans-SNARE complexes are not formed during capacitation.
Male Reproductive Tract
This study shows the equal contribution of clear and principal cells to proton secretion, and the dual role of principal cells in bicarbonate and proton secretion, depending on luminal cues.
Kiss1 hexadecapeptide directly regulates gonadotropin-releasing hormone 1 in the scombroid fish, chub mackerel†
Kiss1 hexadecapeptide (Kiss1-16) is the mature Kiss1 form in scombroid fish, chub mackerel, and may directly regulate reproductive axis via control of GnRH1 neuronal activity.
Vascular endothelial growth factors C and D may promote angiogenesis in the primate ovulatory follicle
VEGFC and VEGFD produced by granulosa cells of the ovulatory follicle may contribute to follicular angiogenesis and ovulation.
Expression analysis of growth differentiation factor 9 (Gdf9/gdf9), anti-müllerian hormone (Amh/amh) and aromatase (Cyp19a1a/cyp19a1a) during gonadal differentiation of the zebrafish, Danio rerio
Oocytes may influence gonadal differentiation by releasing growth differentiation factor 9.
Endocrine changes, fetal growth, and uterine artery hemodynamics after chronic estrogen suppression during the last trimester of equine pregnancy
Chronic suppression of estrogen synthesis during the last trimester of equine gestation reduced fetal growth but had no effect on uterine artery hemodynamics, maintenance of pregnancy, or neonatal viability.
Chronic hypoxia upregulates DNA methyltransferase and represses large conductance Ca2+-activated K+ channel function in ovine uterine arteries
Gestational hypoxia promotes hypermethylation and repression of KCNMB1 gene and BKCa channel function in uterine arteries by upregulating DNMT expression and activity, leading to maladaptation of uterine circulation during pregnancy.
Effects of acute exposure to a high-fat, high-sucrose diet on gestational glucose tolerance and subsequent maternal health in mice
Exposure to a high-fat, high-sucrose diet just before and during pregnancy in mice impairs islet cell expansion, resulting in glucose intolerance of pregnancy and the development of glucose intolerance later in life.
Fertility of cold-stored mouse sperm is recovered by promoting acrosome reaction and hyperactivation after cholesterol efflux by methyl-beta-cyclodextrin
Methyl-β-cyclodextrin removed cholesterol from the entire plasma membrane in cold-stored sperm and restored fertility by inducing the acrosome reaction and hyperactivation.
The ubiquitous isoform of Na/K-ATPase (ATP1A1) regulates junctional proteins, connexin 43 and claudin 11 via Src-EGFR-ERK1/2-CREB pathway in rat Sertoli cells
The ATP1A1-Src-EGFR-ERK1/2-CREB pathway regulates expression of connexin 43 and claudin 11 in rat Sertoli cells; consequently, it is involved in formation and function of junctional complexes.
Identification of KIAA1210 as a novel X-chromosome-linked protein that localizes to the acrosome and associates with the ectoplasmic specialization in testes
KIAA1210, which is a novel X-chromosome-linked protein, is localized to the acrosome and associates with ectoplasmic specialization, and has a direct or indirect interaction with DNA topoisomerase 2.
Progressive obesity alters ovarian insulin, phosphatidylinositol-3 kinase, and chemical metabolism signaling pathways and potentiates ovotoxicity induced by phosphoramide mustard in mice†
Obesity alters ovarian signaling pathways that regulate primordial follicle activation and chemical biotransformation, thereby potentially contributing to reproductive dysfunction.
PM exposure induces DNA damage and subsequent repair in ovaries of exposed mice, and this response is abrogated in obese females.