PhD Research Fellow and Specialty Registrar in Anaesthesia and Critical Care Medicine, Critical Care Research Area, NIHR Southampton Respiratory Biomedical Research Unit, University Hospital Southampton NHS Foundation Trust, Southampton, UK
Smiths Medical Professor of Anaesthesia and Critical Care, UCL Director, UCLH/UCL/RFH Research Support Centre, Director of Research & Development and National Clinical Adviser, Department of Health Enhanced Recovery Partnership, UK
Oxygen is vital for life-sustaining aerobic respiration in humans and is arguably the most commonly administered drug in anaesthesia and critical care medicine. Within the mitochondrial inner membrane, oxygen acts as the terminal electron acceptor at the end of the electron transport chain whereby oxidative phosphorylation results in the synthesis of adenosine triphosphate (ATP), the coenzyme that supplies energy to all active metabolic processes. This article will discuss the key physiological concepts underpinning the movement of oxygen within the human body and also highlight some clinical applications that serve as examples of these concepts.
With respect to human physiology, oxygen transport can be divided into that occurring through convection and that occurring by diffusion. In this context, convection describes the...