The fetal circulation (Fig. 1) is markedly different from the adult circulation. In the fetus, gas exchange does not occur in the lungs but in the placenta. The placenta must therefore receive deoxygenated blood from the fetal systemic organs and return its oxygen rich venous drainage to the fetal systemic arterial circulation. In addition, the fetal cardiovascular system is designed in such a way that the most highly oxygenated blood is delivered to the myocardium and brain. These circulatory adaptations are achieved in the fetus by both the preferential streaming of oxygenated blood and the presence of intracardiac and extracardiac shunts. Thus, the fetal circulation can be defined as a ‘shunt-dependent’ circulation.
In the fetus, gas exchange occurs in the placenta.
The fetal circulation is ‘shunt-dependent’.
Cardiac output in the fetus is defined in terms of combined ventricular output (CVO).
The presence of fetal haemoglobin and a high CVO help maintain oxygen delivery in the fetus despite low oxygen partial pressures.
The transition from fetal to neonatal life involves closure of circulatory shunts and acute changes in pulmonary and systemic vascular resistance.
In the fetus, deoxygenated blood arrives at the placenta via the umbilical arteries and is returned to the fetus in the umbilical vein. The partial pressure of oxygen (
Desaturated blood (
Combined ventricular output (CVO)
In the adult circulation, where the circulatory system is in series and there are no shunts, the stroke volume of the RV should equal that of the LV and cardiac output can be defined in terms of the volume of blood ejected by one ventricle in 1 min. In the fetus, as a result of intracardiac and extracardiac shunting, the stroke volume of the fetal LV is not equal to the stroke volume of the RV. The RV receives about 65% of the venous return and the LV about 35%. Thus, in the shunt dependent circulation of the fetus, the situation is much more complex and cardiac output must be defined in different terms.
The cardiac output of the fetus can only be spoken of in terms of the total output of both ventricles—the combined ventricular output (CVO).2 About 45% of the CVO is directed to the placental circulation with only 8% of CVO entering the pulmonary circulation.
Control of the fetal circulation
Control of the fetal circulation is extremely complex and poorly understood. It is set against a background of multiple control processes, which mature and develop with gestational age. Circulating catecholamines, other circulating hormones and locally released vasoactive substances all play a part.3 Circulating catecholamines exert their effect through activation of α- and β-adrenergic receptors. These receptors mature during early gestation independently of the autonomic innervation process, which occurs much later and is probably only completed during the neonatal period. The peripheral circulation of the fetus appears to be under a tonic adrenergic influence (predominantly vasoconstriction), probably mediated by circulating catecholamines and in particular by norepinephrine. Other factors such as arginine vasopressin (AVP) and the renin–angiotensin system may also have a role.
The high PVR of the fetus is multifactorial in origin. The fetal pulmonary arterioles have a high muscle mass and resting tone. The fetal lungs are collapsed and there is a low resting oxygen tension. The DA also contains muscle that is sensitive to oxygen tension and vasoactive substances. DA patency in utero is maintained by the low oxygen tension and the vasodilating effect of prostaglandin E2 (PGE2).
Oxygen delivery in the fetus
Oxygen delivery is related to CVO and the oxygen content of blood. Oxygen content of blood is determined mainly by the quantity of haemoglobin and its oxygen saturation. The fetus has a high haemoglobin concentration (∼16 g dl−1 at term), with a high percentage of haemoglobin F (HbF), which has a lower content of 2,3-diphosphoglycerate, thus shifting the oxygen dissociation curve to the left (Fig. 2). This favours oxygen uptake in the placenta, where, if
The fetal circulation in transition
As the fetus begins its transition to post-natal life, several cardiopulmonary adaptations must be made. Gas exchange must be transferred from the placenta to the lungs, the fetal circulatory shunts must close and the left ventricular output must increase. At birth, several factors are involved in the cessation of the placental circulation.4 The umbilical vessels are reactive and constrict in response to longitudinal stretch and the increase in blood
With the placental circulation removed there is a dramatic fall in the flow through the ductus venosus and a significant fall in the venous return through the IVC. The ductus venosus closes passively 3–10 days after birth. During late gestation there is a gradual reduction in PVR. At birth, after expansion of the lungs, there is a dramatic fall in PVR and an 8–10-fold increase in pulmonary blood flow. In fetal lambs it has been shown that mechanical expansion of the lungs with non-oxygenated gas results in a massive fall in PVR. This fall in PVR may relate simply to lung expansion opening up pulmonary vessels. However, it is thought to be mediated, in part, by stimulation of pulmonary stretch receptors resulting in reflex vasodilatation. Better oxygenation of neonatal blood also reverses the pulmonary vasoconstriction caused by hypoxia, further reducing PVR.
The increase in pulmonary blood flow leads to a massive rise in pulmonary venous return to the LA. The decrease in IVC flow, described above, results in a fall in venous return to the RA. These two factors allow the pressures in the LA and RA to equalize. At this point the flap of the foramen ovale is pushed against the atrial septum and the atrial shunt is effectively closed. This initial closure of the foramen ovale occurs within minutes to hours of birth. Anatomical closure occurs later via tissue proliferation.
Concomitant with the drop in PVR, the shunt at the level of the DA becomes bi-directional. The exact mechanism of ductal closure is not known but the increased
Changes in cardiac output
For the term fetus, CVO is high (∼400–500 ml kg−1 min−1). Equally in the neonatal period, the cardiac output is extremely high, ranging from 275 to 425 ml kg−1 min−1 (remember this is defined in terms of single ventricular output). Indeed the neonatal cardiac index has been measured at 4.0 litre min−1 m−2 at 1 h of age. The cardiac output of the neonate is tightly coupled with oxygen consumption. This increases after birth owing to the increased metabolic demands of thermogenesis, the increased work of breathing and the increased caloric utilization secondary to growth. The disparity between the LV and RV outputs disappears as the neonatal circulation is established.
The fetus, in late gestation appears to have a limited ability to augment its cardiac output when given added filling volume.7 The neonatal heart, on the other hand, can significantly increase its cardiac output with volume loading. The exact mechanism for this change is unknown but may be a maturational effect of the myocardium, allowing it to perform better.
The high resting cardiac output of the neonate, however, results in a somewhat limited reserve. The situation gradually improves as the cardiac output of the neonate decreases over the first few months of life. HbF is replaced by adult haemoglobin resulting in better oxygen delivery to the tissues. This change in oxygen delivery is thought to result in the gradual decrease in cardiac output.
Return to the fetal circulation
The changes outlined above, which occur in the transition to neonatal life, may not be permanent. Given the correct combination of circumstances, it is possible for a normal neonate to revert back to a fetal-type circulation, a pathophysiological state termed persistent fetal circulation (PFC).
In the neonate, pulmonary arterioles remain very reactive and will constrict in response to certain stimuli such as hypoxia, hypercarbia, acidosis and cold. This can lead to a rise in PVR that, in turn, favours right to left shunting through the FO and DA, which have not yet anatomically closed. This leads the neonate to revert to a fetal pattern of circulation with one major difference—there is no placenta to provide oxygenation. A vicious cycle of worsening hypoxia and acidosis is then set in motion (Fig. 4).
In a review of this size it is impossible to cover all the possible abnormalities associated with congenital heart disease (CHD). However, included below is a brief discussion of a few types of CHD that helps illustrate how the change from fetal circulation to neonatal circulation can have significant effects.
The forms of CHD discussed below are well-tolerated in utero. Other forms of CHD can result in severe compromise of the fetal circulation and early fetal death.
Patent ductus arteriosus (PDA)
The DA normally closes within the first 24 h of birth. Failure of the DA to close results in a left to right shunt (Fig. 5). This is because of the rise in SVR and fall in PVR that occurs after birth. In other words, the shunt is in the opposite direction to that in the fetus. The magnitude of the shunt increases as the PVR continues to fall. This results in an increased volume and workload with respect to the LA and LV and, eventually, left heart failure.
Ventricular septal defects
Ventricular septal defects (VSD) are one of the most common forms of CHD. They are well-tolerated in the fetus, as LV and RV pressures are equal. After birth the circulatory effects of a VSD are dependent on the size of the defect and the balance between PVR and SVR. In neonates with a large VSD, as SVR rises and PVR falls, a significant left to right shunt through the VSD becomes apparent. As PVR continues to fall during the first weeks of life, this shunt increases leading to congestive heart failure.
Tetralogy of Fallot
Tetralogy of Fallot (TOF) is one of the most common congenital heart malformations (Fig. 6). It is now recognized that the two most important features of TOF are: (i) RV outflow obstruction, nearly always infundibular and/or valvular in location, often associated with a hypoplastic pulmonary artery; and (ii) a large subaortic VSD associated with malalignment of the conal septum.
In the fetus, depending on the severity of the obstruction to pulmonary blood flow, the aorta will carry a larger percentage of CVO. If the obstruction to pulmonary blood flow is very severe, blood flow to the lungs will be supplied via the DA from the descending aorta (i.e. the reverse of the normal situation). Even this significantly altered circulation results in no problems during intra-uterine life.
After birth, the effect of duct closure will depend on the severity of the pulmonary obstruction. If the pulmonary obstruction is severe, the neonatal circulation is said to be ‘duct-dependent’ and duct closure will lead to severe cyanosis. Re-establishment of the ductal flow by means of a prostaglandin infusion is an important intervention used to stabilize these neonates.
Transposition of the Great Arteries
Transposition of the great arteries (TGA) results from abnormal rotation and septation of the arterial truncus during embryogenesis (Fig. 7).8 The aorta arises from the RV and the pulmonary artery from the LV. The FO and DA develop as normal and there are no major circulatory consequences of this lesion in utero. After birth, because the pulmonary and systemic circulations are arranged in parallel rather than in series, survival depends on the presence of one or more mixing points (ASD, VSD or PDA) between the two circulations in order to achieve an arterial oxygen saturation compatible with life. Thus, newborns with TGA and an intact ventricular septum (IVS) who have only a small patent FO (PFO) or ASD will be severely cyanosed after closure of the DA. Sometimes this severe cyanosis is associated with acidosis and cardiovascular collapse.
Immediate management of these neonates involves re-establishing ductal patency using a PGE1 infusion and, if necessary, creating an ASD by means of a balloon atrial septostomy (BAS) to allow a larger degree of mixing at the atrial level. BAS is usually performed under echocardiographic guidance on the Paediatric Intensive Care Unit. Once the neonate has been stabilized, complete surgical repair of the lesion can be undertaken electively at a later date.
See multiple choice questions 81–84.