smokers were 30% more likely to develop psoriasis

...K. Danielsen; A.O. Olsen; T. Wilsgaard; A.‐S. Furberg The first appearance of psoriasis can occur at any age, and is most likely to develop between the ages of 15 and 30 years. ¹⁸ Some investigators debate that there is type I and type II psoriasis, depending on the age of onset...

...-sectional data, so it is not known whether this low-grade 17 systemic inflammation is simply a spill-over effect from the skin or an actual contributing source to the 18 development of psoriasis. 19 20 What does this study add? 21 In this prospective cohort study of more than 100,000 individuals, we...

... in the Japan registration study had a lower mean body mass index (BMI) and higher mean percentage body surface area of psoriasis and Psoriasis Area and Severity Index scores. Baseline medical history across studies showed that roughly half of patients were current/former smokers; common comorbidities included...

... and had a longer psoriasis duration than those in the higher BMI categories. Other variables were similarly distributed across BMI categories. At baseline, compared with the psoriasis‐only group, those who developed PsA were younger (44·7 vs. 48·5 years), were more likely to have severe psoriasis (29% vs...

... and larger populations might reveal a notable association between smoking cessation and GPP. Furthermore, we also found that the risk-reducing effects on psoriasis, including PsV, PPP and GPP, were more pronounced in individuals with an extended smoking cessation period, represented by sustained ex-smokers...

... the development of psoriasis, death, transfer out of practice or the end of the study period (1986–2012). Observations were censored in both cohorts when psoriasis was not recorded in THIN during this study period. Cox proportional hazards models were used to determine the hazard ratios (HRs) with 95% confidence...

... psoriasis verified by a dermatologist and more than two episodes of systemic or inpatient treatment. Patients with a past or present history and/or symptoms of cardiovascular diseases (myocardial infarction, stroke, peripheral artery disease or coronary heart disease) were excluded. Using these criteria, 32...

...) summarizes the background characteristics of the two registry populations. Broadly, patients from PsoBest were older and more likely to be current smokers, drink more alcohol, be currently working and have less comorbidity, but were less likely to have a BMI > 30 kg m⁻² or depression. Regarding...

..., NHS II and HPFS, individuals with a history of smoking were 1·39 times more likely to develop incident psoriasis, after multivariate adjustment for confounders (95% CI 1·27–1·52), and current smokers were nearly twice as likely to develop psoriasis, compared with nonsmokers (adjusted OR 1·94, 95% CI 1...

..., in particular, has been associated with triggering psoriasis onset and development of more severe disease. 8   13 The exact mechanism by which smoking impacts psoriasis is unknown and is likely complex. Hypotheses include alterations to smokers’ neutrophil morphology and function, higher levels of oxidative...

...‐density lipoprotein cholesterol plasma levels were similar. Although psoriasis patients were more frequently smokers, the association of psoriasis with metabolic syndrome was independent from smoking. There was no correlation between severity of psoriasis and prevalence of metabolic syndrome. Psoriatic...

...; 66·2%) and those with body mass index (BMI) ≥ 30 (5690 of 7860; 72·4%). Overall incidence of HS was 0·20% (7860 of 3 924 310) among tobacco smokers and 0·11% (8430 of 8 027 790) among nonsmokers (P <0·001). Incidence was greatest among tobacco smokers who were aged 30–39 years (0...

... that patients with psoriasis who were HLA-C*06:02 + were more likely to achieve PASI 75 and PASI 90 in response to treatment with ustekinumab compared with patients who were HLA-C*06:02−. ²² The better response with ustekinumab in patients with psoriasis who were HLA-C*06:02 + compared with those...

... and psoriasiform irAEs is approximately 4% of all skin toxicities. A cohort study by the European Network for Cutaneous Adverse Event to Oncologic Drugs group reported that 70% of 115 patients had no history of psoriasis. Ten per cent of psoriasiform irAEs were categorized as severe, involving more than 30% BSA...

... and 70% for infliximab. Longer drug survival is more likely in the significant subgroup of patients in whom a very low dose of FAEs is sufficient to control disease. The reasons for this are unclear. Fumaric acid esters (FAEs) have been used widely for over 30 years in the management of psoriasis...

... (n =22)] presented no significant differences in associated phenotypes; Table 5 presents an analysis of methotrexate as a representative of this group. However, with respect to etanercept, patients with thick‐plaque psoriasis were more likely to report a complete response than were...

... (SSP), Spielberger State‐Trait Anxiety Inventory and Beck Depression Inventory. Psoriasis severity was assessed by the Psoriasis Area and Severity Index. Results Patients with early‐onset psoriasis (age < 20 years) were significantly more anxious and depressed than patients with late‐onset...

... cumulative dose according to product prescribing information. 45 We have shown that patients on etanercept, but not ustekinumab, were less likely to achieve a DLQI of 0/1 compared with those on adalimumab. This finding aligns with other studies reporting that patients are more likely to discontinue...

...%), diabetic (11%), dyslipidaemic (28%), hypertensive (26%), smokers (33%), and had a familial cardiovascular disease history (24%) (Table 2 ). The metabolic syndrome was diagnosed in 15% of the patients, and 7% suffered from MACE. Compared with women, men were significantly more often overweight or obese...

...‐1980s, a Norwegian cross‐sectional study found that male smokers had an increased risk of psoriasis. ¹⁷ A subsequent cohort study in the U.S.A. showed that female patients with newly diagnosed psoriasis were significantly more likely to be smokers than women in the local general population...