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A Shankar, M Loizidou, G Aliev, S Fredericks, D Holt, P B Boulos, G Burnstock, I Taylor, Raised endothelin 1 levels in patients with colorectal liver metastases, British Journal of Surgery, Volume 85, Issue 4, April 1998, Pages 502–506, https://doi.org/10.1046/j.1365-2168.1998.00660.x
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Abstract
Endothelin 1 (ET-1), a vasoconstrictor peptide, has been implicated as a tumour growth stimulator and an angiogenesis factor.
To assess the involvement of ET-1 in colorectal cancer, immunoelectron microscopy for ET-1 was performed in colorectal liver metastases and normal liver (n = 6). ET-1 plasma levels were measured by radioimmunoassay in patients with colorectal cancer, with (n = 18) and without (n = 12) liver metastases, and in controls (n = 22).
In normal liver, ET-1 was present in endothelial cells; in tumour, it was observed in endothelial cells, tumour cells and myofibroblasts. Mean(s.d.) plasma ET-1 levels were 2·75 (1·37) pg/ml in controls, 4·53(1·61) pg/ml in patients with colorectal liver metastases (P = 0·001) and 3·92(1·32) pg/ml in patients without metastases (P = 0·02).
ET-1 was present in various cell types within colorectal liver metastases and raised levels were found in the plasma of patients with colorectal cancer. ET-1 may not only modulate tumour vascular tone but also act on tumour growth and angiogenesis, both locally and systemically.
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Author notes
Presented to the Surgical Research Society in Birmingham, UK, June 1996 and published in abstract form as Br J Surg 1996; 83: 1628.
