
Contents
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The Serotonergic System The Serotonergic System
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Serotonergic Mechanisms of OCD Treatment Serotonergic Mechanisms of OCD Treatment
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Serotonergic Genetics of OCD Serotonergic Genetics of OCD
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Imaging Studies of the Serotonergic System Imaging Studies of the Serotonergic System
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Serotonergic Changes in Response to Treatment Serotonergic Changes in Response to Treatment
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The Dopaminergic System The Dopaminergic System
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Dopaminergic Mechanisms in the Treatment of OCD Dopaminergic Mechanisms in the Treatment of OCD
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Dopaminergic Genetics of OCD Dopaminergic Genetics of OCD
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Imaging Studies of the Dopaminergic System Imaging Studies of the Dopaminergic System
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Dopaminergic Changes in Response to Treatment Dopaminergic Changes in Response to Treatment
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The Glutamatergic System The Glutamatergic System
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Glutamatergic Imaging Studies Glutamatergic Imaging Studies
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Genetics of Glutamate Systems in OCD Genetics of Glutamate Systems in OCD
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Glutamatergic Mechanisms in the Treatment of OCD Glutamatergic Mechanisms in the Treatment of OCD
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Glutamate Changes in Response to Treatment Glutamate Changes in Response to Treatment
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The GABA System The GABA System
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Conclusion Conclusion
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References References
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59. Personality Pathology in OCD: Comorbidity and Contrast with OCPD and Other Personality Disorders
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25. Neurotransmitter Dysregulation in OCD
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Published:September 2017
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Abstract
Obsessive-compulsive disorder (OCD) is associated with abnormalities in the cortico-striatal–thalamic–cortical (CSTC) circuitry, and may be associated with dysregulation of neurotransmitters within this network. The major neurotransmitters of the CSTC are serotonin, dopamine, glutamate and γ-aminobutyric acid (GABA. This chapter reviews evidence of the involvement of these neurotransmitters in OCD from pharmaocological, genetic, and imaging studies. yielding an integrated neurotransmitter model of OCD. It concludes that the neurotransmitter model of OCD involves dopaminergic and glutamatergic overactivity in frontostriatal pathways, along with diminished serotonergic and GABAergic neurotransmission in frontolimbic systems. These neurotransmitter imbalances may explain frontostriatal hyperactivity and impaired frontolimbic emotion regulation. Advancing our understanding of neurotransmitter abnormalities in OCD, and how abnormalities in different transmitter systems relate to one another, holds promise for the development of new pharmacotherapies.
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