
Contents
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11.1 Pharmacology 11.1 Pharmacology
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11.2 Clinical studies 11.2 Clinical studies
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11.2.1 Longer-term use of denosumab 11.2.1 Longer-term use of denosumab
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11.2.2 Denosumab versus alendronic acid 11.2.2 Denosumab versus alendronic acid
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11.3 Practicalities of clinical use 11.3 Practicalities of clinical use
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11.3.1 Renal impairment 11.3.1 Renal impairment
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11.3.2 Stopping denosumab 11.3.2 Stopping denosumab
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11.4 Adverse events 11.4 Adverse events
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11.5 Other indications 11.5 Other indications
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11.5.1 Cancer-related conditions 11.5.1 Cancer-related conditions
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11.5.2 Male osteoporosis 11.5.2 Male osteoporosis
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11.5.3 Glucocorticoid-induced osteoporosis 11.5.3 Glucocorticoid-induced osteoporosis
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11.5.4 Children 11.5.4 Children
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11.6 Summary 11.6 Summary
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Key references Key references
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Cite
Abstract
Denosumab is a fully human monoclonal antibody to the receptor activator of nuclear factor κB ligand (RANKL) and acts as an anti-resorptive agent by inhibiting osteoclast function.
Denosumab (60 mg) is given by 6-monthly subcutaneous injection to treat post-menopausal osteoporosis.
The randomized controlled trial FREEDOM showed denosumab significantly reduced vertebral, non-vertebral, and hip fractures over 3 years in post-menopausal women.
Denosumab has been well tolerated in trials to date but carries a small increased risk of infections, e.g. cellulitis.
In renal failure, denosumab does not need a dose adjustment; however, it may increase the risk of hypocalcaemia.
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