From Development to Degeneration and Regeneration of the Nervous System
From Development to Degeneration and Regeneration of the Nervous System
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Abstract
This book describes current information about the three areas mentioned in the title: neuronal migration and development, degenerative brain diseases, and neural plasticity and regeneration. The chapters in the first section of the book examine the cellular and molecular mechanisms by which neurons are generated from the ventricular zone in the forebrain and migrate to their destinations in the cerebral cortex. This description of cortical development also includes discussions of the Cajal-Retzius cell. Another chapter provides insight about the development of another forebrain region, the hypothalamus. The remaining chapters of the first section examine the clinical relevance of brain development in certain disease states in humans. The second section begins with details about the dopaminergic neurons in the substantia niger and their loss in Parkinson's disease. Two subsequent chapters describe changes in brain aging, including changes in the numbers of myelinated axons. Other chapters in this section describe important cellular and molecular changes found in Alzheimer's disease and human epilepsy. The last section begins with a chapter on how the brain's own stem cells provide newly generated neurons to the hippocampal dentate gyrus and how these neurons become integrated into neural circuitry. Then two chapters examine some of the neuroplastic changes that take place in motor and sensory cortices of awake behaving primates. The concluding two chapters address the issue of regeneration in the injured spinal cord and the factors that may contribute to its success.
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Front Matter
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Part 1 Cajal’s load
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Part 2 Neuronal Migration and Development
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Two
Tangential Cell Movements During Early Telencephalic Development
Juan A. De Carlos andFernando García-Moreno
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Three
Genetic Control of Cajal–Retzius Cell Development
Amaya Miquelajáuregui andAlfredo Varela-Echavarría
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Four
Development of the Paraventricular Nucleus of the Hypothalamus
Larry W. Swanson
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Five
Neural Tube Defects: New Insights on Risk Factors
Enrique Pedernera and others
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Six
Quantitative Electroencephalography in the Normal and Abnormal Developing Human Brain
Thalía Harmony and others
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Two
Tangential Cell Movements During Early Telencephalic Development
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Part 3 Degenerative Brain Diseases
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Seven
The Nigro-Striatal DA Neurons and Mechanisms of Their Degeneration in Parkinson’s Disease
Kjell Fuxe and others
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Eight
Degeneration and Regeneration of Myelin in the Central Nervous System of the Aging Monkey
Alan Peters
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Nine
Degeneration in Canine Brain Aging
Elizabeth Head
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Ten
Alzheimer’s Disease–Related Mechanisms of Neuronal Dysfunction and Degeneration: Studies in Human Cortical Neurons
Jorge Busciglio andAtul Deshpande
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Eleven
Aberrant Cells and Synaptic Circuits in Pediatric Epilepsy Surgery Patients
Carlos Cepeda and others
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Seven
The Nigro-Striatal DA Neurons and Mechanisms of Their Degeneration in Parkinson’s Disease
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Part 4 Neural Plasticity and Regeneration
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Twelve
Developmental Profile of Newly Generated Granule Cells in the Adult Rodent Dentate Gyrus
Charles E. Ribak and others
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Thirteen
Functional Architecture of Directional Tuning in the Primate Motor Cortex During 3D Reaching
Hugo Merchant and others
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Fourteen
Neural Codes for Perceptual Decisions
Ranulfo Romo and others
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Fifteen
Human Neural Stem Cell–Mediated Repair of the Contused Spinal Cord: Timing the Microenvironment
Brian J. Cummings and others
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Sixteen
Spinal Cord Injury Pathology Differs with Injury Type, Age, and Exercise
Monica M. Siegenthaler andHans S. Keirstead
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Twelve
Developmental Profile of Newly Generated Granule Cells in the Adult Rodent Dentate Gyrus
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End Matter
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