
Contents
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10.1 Cellular senescence and telomeres 10.1 Cellular senescence and telomeres
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10.2 Models of tissue aging and maintenance 10.2 Models of tissue aging and maintenance
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10.2.1 The probabilistic model of Op den Buijs et al. 10.2.1 The probabilistic model of Op den Buijs et al.
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10.2.2 A continuum model 10.2.2 A continuum model
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10.3 Asymmetric stem-cell division 10.3 Asymmetric stem-cell division
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10.4 Maintaining the stem-cell reservoir 10.4 Maintaining the stem-cell reservoir
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10.4.1 The Roeder–Loeffler model 10.4.1 The Roeder–Loeffler model
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10.4.2 A deterministic model 10.4.2 A deterministic model
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References References
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Exercises Exercises
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Cite
Abstract
Cellular aging, commonly referred to as cellular senescence, is thought to be a ‘programmed’ cell fate in a similar sense that apoptosis is somehow programmed to happen to certain cells during development. A specific kind of aging called replicative senescence is characterized by a cell's permanent exit from the cell cycle after undergoing a certain number of divisions. One of the known causes of replicative senescence is telomere shortening after each division. Telomeres are the ends of linear eukaryotic chromosomes. This chapter discusses a model involving replicative senescence of cells lining the walls of blood vessels. Both a probabilistic model tracking individual cells and a deterministic model of the cell population dynamics are illustrated. Exercises are given at the end of the chapter.
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