Phenotypic analysis of 303 multiplex families with common epilepsies
Abou-Khalil et al.—of the Epi4K consortium—study clinical aggregation patterns in 303 multiplex families with unprovoked seizures. The resulting phenotypic information provides a valuable resource for interpreting sequencing data.
Modelling apolipoprotein E e3/4 allele-associated sporadic Alzheimer’s disease in an induced neuron
Kim et al. use human and mouse induced neuron-based models to dissect the molecular mechanisms underlying the association between APOE e3/4 and Alzheimer’s disease, and reveal an interaction between APOE e3/4 and another Alzheimer’s disease susceptibility gene.
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The spectrum of structural and functional network alterations in malformations of cortical development
Using structural and functional MRI, Hong et al. map whole-brain network anomalies across the spectrum of malformations of cortical development. Time of insult during corticogenesis appears to affect the severity of network reconfiguration.
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2016 Highlights
This free to access selection of key papers and blog posts published in 2016 covers such topics as Alzheimer’s, Parkinson’s, autism, pregnancy, and much more.
Parkinson's Collection
In 1817 James Parkinson identified the individual symptoms of Parkinson's disease. We are celebrating the 200 years of progress in our understanding of the signs and symptoms, the cause, and the treatment of the disease.
Conscious unity, split perception
Pinto and colleagues re-investigated the fundamental question of conscious unity in split-brain patients. They noticed that even in the existing literature on split-brain patients, the results are much more complicated than the clear-cut picture presented in reviews and textbooks.
Can hypnosis improve the functioning of injured brains?
Patients with brain injuries scored much lower than the healthy population at baseline on two measures of working memory. However, after four sessions of hypnosis, they improved on both outcome measures to slightly above the population mean.
How does acupuncture work? The role of S1 remapping
Vitali Napadow demonstrated that both real and sham acupuncture improved CTS symptoms. However, objective/physiological outcomes showed specific improvement for acupuncture, compared to sham acupunctures.
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