The non-motor syndrome of primary dystonia: clinical and pathophysiological implications

Abstract

Dystonia is typically considered a movement disorder characterized by motor manifestations, primarily involuntary muscle contractions causing twisting movements and abnormal postures. However, growing evidence indicates an important non-motor component to primary dystonia, including abnormalities in sensory and perceptual functions, as well as neuropsychiatric, cognitive and sleep domains. Here, we review this evidence and discuss its clinical and pathophysiological implications.

primary dystonia, non-motor, sensory, depression, endophenotypes, pathophysiology, quality of life