Acute surgical vs non-surgical management for ocular and peri-ocular burns: a systematic review and meta-analysis

Background Burn-related injury to the face involving the structures of the eyes, eyelids, eyelashes, and/or eyebrows could result in multiple reconstructive procedures to improve functional and cosmetic outcomes, and correct complications following poor acute phase management. The objective of this article was to evaluate if non-surgical or surgical interventions are best for acute management of ocular and/or peri-ocular burns. Methods This systematic review and meta-analysis compared 272 surgical to 535 non-surgical interventions within 1 month of patients suffering burn-related injuries to 465 eyes, 253 eyelids, 90 eyelashes, and 0 eyebrows and evaluated associated outcomes and complications. The PubMed, Embase, Cochrane Library, Web of Science, and Scopus databases were systematically and independently searched. Patient and clinical characteristics, surgical and medical interventions, outcomes, and complications were recorded. Results Eight of the 14,927 studies queried for this study were eligible for the systematic review and meta-analysis, with results from 33 of the possible 58 outcomes and complications using Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) and Cochrane guidelines. Surgery was associated with standard mean differences (SMD) 0.44 greater visual acuity on follow-up, SMD 1.63 mm shorter epithelial defect diameters on follow-up, SMD 1.55 mm greater changes in epithelial diameters from baseline, SMD 1.17 mm2 smaller epithelial defect areas on follow-up, SMD 1.37 mm2 greater changes in epithelial defect areas from baseline, risk ratios (RR) 1.22 greater numbers of healed epithelial defects, RR 11.17 more keratitis infections, and a 2.2 greater reduction in limbal ischemia compared to no surgical intervention. Conclusions This systematic review and meta-analysis found that compared to non-surgical interventions, acute surgical interventions for ocular, eyelid, and/or eyelash burns were found to have greater visual acuity on follow-up, shorter epithelial defect diameters on follow-up, greater changes in epithelial diameters from baseline, smaller epithelial defect areas on follow-up, greater changes in epithelial defect areas from baseline, greater numbers of healed epithelial defects, more keratitis infections, and a greater reduction in limbal ischemia, possibility preventing the need of a future limbal stem cell transplantation. Electronic supplementary material The online version of this article (10.1186/s41038-019-0161-4) contains supplementary material, which is available to authorized users.


Background
Burn-related injury to the face involving the structures of the eyes, eyelids, eyelashes, and/or eyebrows could result in multiple reconstructive procedures to improve functional and cosmetic outcomes, and correct complications following poor acute phase management. Burn injury to ocular structures requires patient transfer to specialized burn centers, where early evaluation by an oculoplastic surgeon may prevent long-term morbidity [1]. The majority of ocular burns do not require surgical interventions, and rates of long-term morbidity have been reported as low as 4.5% with medical management alone [2][3][4]. Prior associated risk factors identified for surgical interventions after ocular burns have been deep eyelid burns, flame burns, increasing severity of corneal injuries, periorbital edema, visual loss on presentation, and keratitis [2].
This review provides healthcare providers with insight on outcomes and complications in burn-related injury to the eyes, eyelids, eyelashes, and eyebrows. Surgeons may be more or less likely to perform surgical procedures if they can determine when they are most necessary. Patients can be informed early of realistic expectations following surgical or medical management alone when consenting to treatment.
This new systematic review and meta-analysis compared surgical to non-surgical interventions within 1 month of patients suffering burn-related injuries to the eyes, eyelids, eyelashes, and/or eyebrows. Based on peer-reviewed literature, it was hypothesized that early surgical interventions for severe burn-related injury to the eye, eyelid, eyelash, and/or eyebrow would result in better patient-related outcomes and lower risks of complications, compared to non-surgical interventions alone.

Methods
Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines were followed throughout the literature search process to structure the framework for the review [5].

Selection criteria
The participants, interventions, comparisons, outcomes, and study design (PICOS) strategy was followed for inclusion throughout the selection process. Participants were of a mean age ≥ 15 years for each study, treated as either inpatients or outpatients, and suffered burn-related injury (thermal, scald, contact, electrical, chemical), to the anatomical subunit of the eye, eyelid, eyelash, and/or eyebrow. Interventions were either surgical (direct closure, split-thickness graft, full-thickness graft, skin substitute, tissue flap, tarsorrhaphy, amniotic membrane transplant (AMT), conjunctival limbal autograft transplantation (CLAT), keratolimbal allograft transplantation, deep anterior lamellar keratoplasty (DALK), and/or penetrating keratoplasty) or non-surgical conventional medical therapy alone (topical lubricants/irrigation, topical antimicrobial, topical anti-glaucoma, oral medication, oral antimicrobial, oral anti-glaucoma, pressure garment) intended for direct care of the ocular, eyelid, eyelash, and/ or eyebrow burn within 1 month of the injury (acute). Comparisons were made between the two intervention groups. Burn patients in the surgical group were compared to the non-surgical group by the ocular, eyelid, eyelash, and/or eyebrow anatomical subunits of the face involved in the burn injury (surgical eyelid compared to non-surgical eyelid). Outcomes measured were burn etiologies; time to burn management in days; percent total body surface area (%TBSA) burned; depth of burn of eyelid, eyelash, and eyebrow (superficial (S), superficial partial thickness (SPT), deep partial thickness (DPT), full thickness (FT)); severity of ocular burn by Dua's classification [6] (Grades I-VI) or Roper-Hall classification [7] (Grades I-IV) for corneal or conjunctival involvement; visual acuity measured by Snellen charts and expressed in decimals or logarithm of minimum angle of resolution (logMAR); change in visual acuity, corneal clarity, corneal haze, change in corneal haze, corneal epithelial defect diameter (mm), change in corneal epithelial defect diameter, epithelial defect area (mm 2 ), change in epithelial defect area, time to epithelialization, and healed epithelial defects by slit-lamp examination and fluorescein staining; pain scale severity measurement graded 0-10; change in pain scale severity score; tear film status measured by tear break-up time (TBUT) in seconds and Schirmer test; limbal ischemia measured in clock hours; hospital length of stay (LOS) in days; inhalation injury; rate of intubation and mechanical ventilation; number of days on a ventilator; intensive care unit (ICU) LOS in days; need for reconstruction; time to reconstruction; and mortality. Complications measured were wound/ocular infection, keloid/hypertrophic scar, eyelid contracture, eyelid ectopian, eyelid entropian, corneal ulceration, corneal vascularization, vision loss, neurovascular bundle compression, symblepharon, and ocular perforation. All outcomes and complications were measured at initial evaluation and at a designated follow-up. Study designs considered were randomized controlled trials (RCTs), clustered RCTs, non-RCTs, retrospective studies, observational studies, prospective studies, case-control studies, and cohort studies. There was no predetermined length of follow-up for participants or specific years considered for publication status. Studies excluded are as follows: if they were not in English, were systematic reviews or review articles with no contribution of new data, non-reviewed peer literature, cadaver studies, animal studies, case-reports, editorial articles, if the full-article was unavailable, patient death occurred prior to evaluation, studies not related to any of the outcomes or complications analyzed, studies with no comparison between surgical and non-surgical interventions, interventions were not performed during the designated acute management time period, involved chronic reconstruction methods, and studies with less than a sample size of 10 in each intervention group to perform the meta-analysis.

Search
A medical library informationist (SMS) conducted the initial literature search using five databases (MEDLINE via PubMed, Embase, Cochrane, Web of Science, and Scopus) from inception to January 18, 2019 (Additional file 1 for search strategy). Reference lists of relevant articles were hand searched to identify additional relevant studies. All references were imported into Covidence (Veritas Health Innovation Ltd., Melbourne, Australia), and reference management software and duplicates were removed.

Data extraction
Two reviewers (KMK and AE) systematically and independently performed the title/abstract screening, followed by full-article review to ensure quality and accuracy throughout the process. Any disagreements regarding studies included or excluded were resolved by discussion. If disagreements were still present after discussion, a third reviewer (CSH) resolved remaining conflict. The following data were extracted qualitatively and quantitatively for outcome and complication variables of interest: authors, year of publication, type of study, sample size, male and female distributions, age, location of burn, time to burn management, burn etiology (thermal, scald, contact, electrical, chemical: acid, alkali, or uncategorized), direct closure, split-thickness graft, full-thickness graft, skin substitute, tissue flap, tarsorrhaphy, AMT, CLAT, keratolimbal allograft transplantation, DALK, penetrating keratoplasty, topical lubricants/irrigation, topical antimicrobial, topical anti-glaucoma, oral medication, oral antimicrobial, oral anti-glaucoma, pressure garment, %TBSA, depth of burn of eyelid, severity of ocular burn by Dua's Grades I-VI, Roper-Hall Grades I-IV, visual acuity in decimals or logMAR, corneal clarity, corneal haze, corneal epithelial defect diameter, epithelial defect area, time to epithelialization, number of healed epithelial defects, pain scale severity measurements, TBUT, Schirmer test, limbal ischemia, hospital LOS, inhalation injury, rate of intubation and mechanical ventilation, number of days on a ventilator, ICU LOS, need for reconstruction, time to reconstruction, mortality, wound/ ocular infection, keloid/hypertrophic scar, eyelid contracture, eyelid ectopian, eyelid entropian, corneal ulceration, corneal vascularization, vision loss, neurovascular bundle compression, symblepharon, and ocular perforation. If there were multiple reports from the same study, one data collection form was completed for the study from all of the reports to avoid duplicating results.

Quality assessment
Two reviewers (KMK and CFG) assessed the risk of bias individually for each study at a study level. This was followed by an assessment across all studies in the metaanalysis using the Cochrane risk of bias tool [8]. Both parts of the Cochrane risk of bias tool were used. The first part was categorized in terms of low, high, or unclear risk. The second part used the quality of evidence GRADE and was categorized in terms of high, moderate, low, and very low quality of evidence. Randomized studies were assessed for the seven risks of bias domains. Nonrandomized studies were assessed for baseline patient characteristics, adjustments for confounding variables, and classifications of interventions. Outcomes and complications from different studies were compared at the same time intervals on follow-up. All studies available meeting criteria were included in data synthesis.

Unit of analysis issues
When a study reported patients with ocular, eyelid, eyelash, and/or eyebrow burns, each anatomical subunit was totaled and reported on an individual basis (assessed eyes, not patients). We extracted data in the form the authors reported. If raw data was unavailable and two different populations were compared in a single study for the same group, those groups were separated as two different studies as long as a minimum of ten eyes/eyelids/eyelashes/eyebrows were available to perform the meta-analysis (author: surgical and non-surgical treatment for ocular burns Dua's Grade II and grade III; author: surgical and non-surgical treatment for ocular burns Dua's Grade II, author: surgical and non-surgical treatment for ocular burns Dua's Grade III). When less than ten eyes/eyelids/eyelashes were categorized into different severities of grades, scores were combined into one group for analysis (Dua's Grade III, n = 6 and Dua's Grade IV, n = 6 receiving AMT, n = 12 Dua's Grade III/ IV receiving AMT). If studies reported multiple anatomical subunits but the sample size was unclear as to which subunit it pertained, the largest identifiable sample was used. Values were not combined to avoid duplicating samples (three cases of eyelid ectropian reported in a sample size involving burns to 30 eyes and 20 eyelids, 3/30 occurrences of eyelid ectropian). Outcomes and complications subdivided by individual grades were combined or averaged from respective studies into one value for appropriate comparison based on dichotomous or continuous data, respectively. Visual acuity expressed as logMAR was converted to a decimal using a standard conversion table [9]. Corneal clarity or transparency was converted to corneal haze [10]. Roper-Hall classified burns were converted to Dua's classified burns to standardize comparisons between studies. Roper-Hall Grade IV burns were converted to Dua's Grade IV/V/VI burns [10]. Severity pain scale measurements were converted to the 0-10 scale across all studies that reported pain. Outcomes were compared at the same follow-up time for all studies. If intervals differed between studies, they were analyzed using descriptive statistics and stated in the review.

Data synthesis and statistical analysis
A summary of findings table was created for seven outcomes of interest using GRADEproGDT software (Evidence Prime Inc., McMaster University, 2015) to include the number of eyes, eyelids, and/or eyelashes, studies for each outcome and complication, the magnitude of effect, and measurement of the quality of evidence. Medians, interquartile ranges, and ranges were converted to means and standard deviations for studies that did not provide the appropriate data [11]. Summary data estimates were converted to risk ratios (RR) to allow proper data comparison and interpretation using the formula and recommendations in the Cochrane Handbook [8,12]. The RevMan software, Version 5.3 (The Nordic Cochrane Center, The Cochrane Collaboration, Copenhagen) was used to perform the meta-analysis. Descriptive statistics were applied to quantify burn severities, different surgical procedures, medications, unequal follow-up times, and any value less than 10 to perform the meta-analysis. Due to the discrepancy in measurements, converting variables in studies to a comparable unit, averaging overall grades within studies, different burn etiologies, different surgical procedures, and demographic characteristics, the random effects model was used in all meta-analysis outcomes and complications [12,13]. RRs with 95% confidence intervals (CIs) were used for dichotomous outcomes and complications. Standard mean differences (SMD) with 95% CI were used for continuous outcomes and complications due to variations in studies.
Study heterogeneity was measured using I 2 . Heterogeneity was examined by inspection of forest plots and tested with chi 2 to determine what percentage of variability was not due to sampling error. I 2 values < 50% were low, medium 50-75%, and high > 75% [14]. If significant heterogeneity was present, we included a structured description and summary of the findings of included studies in the review. Sensitivity analysis using the single study elimination method was used to identify which study contributed to the highest level of heterogeneity. All meta-analysis outcomes were two-tailed, with a significance level set at α of 0.05. No additional analyses were performed during our study.
Of the 58 possible outcomes and complications queried, 47 had attainable results. The outcomes and complications unable to be found in the context of our literature search were scald burns, contact burns, electrical burns, superficial burns, number of days on a ventilator, ICU LOS, need for reconstruction, time to reconstruction, mortality, keloid/hypertrophic scars, and compression of a neurovascular bundle. Table 1 summarizes each individual study from the 8 articles included in our study. Tables 2 and 3 summarize the details for outcomes and complications of interest assessed for each individual study. All seven risks of bias domains were assessed for each study using the Cochrane risk of bias tool (Fig. 2).

Synthesis of results and risk of bias across studies
The 8 studies included in the systematic review were included in the meta-analysis. Of the 58 possible outcomes and complications queried, 33 were eligible for metaanalysis (Additional file 2: Figure S1). Table 4 summarizes the findings of seven outcomes and complications of interest.  [2,16,18,19]. The most common surgery performed for acute ocular burns was AMT for 115 eyes in 5/8 studies [16,17,[19][20][21], followed by DALK for 50 eyes in 1/8 studies [18]. The most common surgery for acute eyelid burns was a full-thickness skin graft for 44 eyelids in 2/8 studies [15,21], followed by tarsorrhaphy for 16 eyelids in 2/8 studies [15,21], and split-thickness skin grafts for 3 eyelids in 1/8 studies [2]. No surgical interventions were described for the acute management of eyelashes and eyebrows. Direct closure, CLAT, keratolimbal allograft transplantation, penetrating keratoplasty skin substitutes, and tissue flap techniques were not available with our criteria in the literature.

Visual acuity
Four studies evaluated mean visual acuity on initial evaluation and at a designated follow-up time of 3 months [17][18][19][20]. Mean initial visual acuity scores ranged from 0.005 to 0.25 in 130 eyes having surgery compared to 0.01 to 0.25 in 132 eyes not having surgery. On the 3-month follow-up, mean visual acuity ranged from 0.014 to 0.6 in eyes having surgery compared to

Corneal haze
Four studies evaluated mean corneal haze grades on initial evaluation and at a designated follow-up time of 3 months for AMT and DALK [18][19][20][21]. Mean initial corneal haze grades ranged from 1.5 to 3.72 in 133 eyes having surgery compared to 1.25 to 3.7 in 135 eyes not having surgery. On 3-month follow-ups, mean corneal haze grades ranged from 0.195 to 2 in eyes having surgery compared to 0.5 to 3.64 in eyes not having surgery. These results were not significant (SMD 0.06; 95% CI − 0.18, 0.3; I 2 = 0%; p = 0.63). The change in corneal haze from baseline ranged from − 0.5 to 3.52 in eyes having surgery compared to − 1.25 to 1.45 in eyes not having surgery. These results were not significant (SMD 0.79; 95% CI − 0.34, 1.93; I 2 = 94%; p = 0.17). After removing, as in the study by Singh et al. that compared DALK surgery to no surgery, heterogeneity dropped from high I 2 = 94% to I 2 = 0% [18]. These results were still not significant.

Epithelial defect diameter
Two studies evaluated mean epithelial defect diameter on initial evaluation and at a designated follow-up time of 21 days [20,21]. Mean initial epithelial defect diameters ranged from 6.4 to 7.74 mm in 33 eyes having surgery compared to 5.6 to 7.19 mm in 35 eyes not having surgery. On day 21 follow-ups, mean epithelial defect diameters ranged from 0.2 to 1.73 mm in eyes having surgery compared to 2.6 to 3.21 mm in eyes not having surgery. The mean epithelial defect diameter was 1.63 mm smaller for eyes having AMT surgery on follow-up with high heterogeneity (SMD − 1.63; 95% CI − 2.87, − 0.38; I 2 = 78%; p = 0.01). No study could be removed to assess the high heterogeneity. The change in epithelial defect diameter from baseline ranged from 5.8 to 6 in eyes having surgery compared to 3 to 3.98 in eyes not having surgery. The change in mean epithelial defect diameter was 1.55 mm greater for eyes having AMT surgery (SMD 1.55; 95% CI 1, 2.1; I 2 = 0%; p < 0.00001).

Epithelial defect area
Four studies evaluated mean epithelial defect area on initial evaluation [16,[19][20][21]. In two studies, mean epithelial defect area was measured at initial evaluation and designated follow-up time of 21 days [20,21]. Mean initial epithelial defect areas ranged from 37.9 to 76.13mm 2 in 33 eyes having surgery compared to 32.6 to 53.88mm 2 in 35 eyes not having surgery. On day 21 follow-ups, mean epithelial defect areas ranged from 0.4 to 1.1mm 2 in eyes having surgery compared to 6.01 to 6.8mm 2 in eyes not having surgery. The mean epithelial defect area was 1.17mm 2 smaller for eyes having AMT surgery on follow-up (SMD − 1.17; 95% CI − 1.69, − 0.65; I 2 = 0%; p < 0.0001). The change in epithelial defect area from baseline ranged from 37.5 to 75 in eyes having surgery compared to 25.8 to 47.87 in eyes not having surgery. The change in mean epithelial defect area was 1.37mm 2 greater for eyes having AMT surgery (SMD 1.37; 95% CI 0.4, 2.34; I 2 = 69%; p = 0.006).

Tear film status
Three studies evaluated tear film status 3 months following management using the Schirmer test and TBUT at 3 months follow-up [16,20,21]. Mean Schirmer tests ranged from 6.88 to 21.2 mm of moisture in 53 eyes having AMT surgery compared to 8.13 to 18 mm of moisture in 59 eyes not having surgery. These results were not significant (SMD 0.07; 95% CI − 0.72, 0.86; I 2 = 76%, p = 0.86). After removing the RCT study by Sharma et al., heterogeneity dropped from high I 2 = 76% to I 2 = 0% [21]. These results were still not significant. Mean TBUT ranged from 4. After removing the retrospective study by Sharma et al., heterogeneity dropped from I 2 = 63% to I 2 = 0% [20]. These results were still not significant.

Time to epithelialization
Three studies evaluated time to epithelialization [19][20][21]. Mean time to epithelialization ranged from 22 to 41.13 days in 83 eyes having AMT surgery compared to 35 to 57.75 days in 85 eyes not having surgery. These results were not significant with high heterogeneity (SMD − 0.8; 95% CI − 1.65, 0.05; I 2 = 85%; p = 0.07). After removing the RCT study by Sharma et al., heterogeneity dropped from high I 2 = 85% to I 2 = 0% [21]. These results were still not significant.

Limbal ischemia
Two studies evaluated limbal ischemia on initial evaluation [19,21] and one study at a designated follow-up time of 3 months with acid and alkali burns involving 30 eyes [21]. Limbal ischemia means on initial evaluation ranged from 4.5 to 9.25 clock hours in eyes having surgery compared to 2.75 to 5.8 clock hours in eyes not having surgery with high heterogeneity (SMD 0.69; 95% CI − 0.32, 1.71; I 2 = 87%; p = 0.18). No study could be removed to assess the high heterogeneity. One study reported on three-month follow-ups, limbal ischemia means were 1.5 clock hours in 15 eyes having AMT surgery compared to 3.7 clock hours in 15 eyes not having surgery (p = 0.015) [21]. No study could be removed to assess the high heterogeneity.

Corneal ulceration
Three studies evaluated the occurrence of corneal ulceration from 6 to 9 months follow-up after burns involving the eyes, eyelids, and eyelashes [2,15,17]. Ulceration occurred in 13 [17]. Split-thickness skin grafts, full-thickness skin grafts, and/or tarsorrhaphies were more likely to result in corneal ulceration.

Vision loss
Two studies evaluated the occurrence of vision loss with burns to the eyes, eyelids, and eyelashes [2,15]. Vision loss occurred in 8/49 (16%) eyes having surgery compared to 10/172 (6%) eyes not having surgery (RR 4.67; 95% CI 2.11, 10.32; I 2 = 0%; p = 0.0001). Surgeries included split-thickness skin grafts, full-thickness skin grafts, and tarsorrhaphies [2]. In the study by Cabalag et al., vision loss was the most common late complication as a result of flame or explosion burns [2]. Surgery was performed in patients with a combination of more severe eyelid burns that were FT and corneal injury than those not having surgery. In the study by Frank et al., vision loss occurred in one patient as a result of the original injury [15].

Ectropian
Three studies evaluated the occurrence of ectropian from 3 to 6-months follow-up after burns involving the eyes, eyelids, and eyelashes [2,15,20]. Ectropian occurred in 24/67 (36%) having surgery compared to 6/192 (3%) not having surgery (RR 7.3; 95% CI 0.8, 66.42; I 2 = 78%, p = 0.08). After removing the study by Cabalag et al., heterogeneity dropped from high I 2 = 78% to medium I 2 = 50% [2]. These results were still not significant. Surgery was performed in patients with a combination of more severe eyelid burns that were FT and corneal injury than those not having surgery.

Discussion
This was the first systematic review and meta-analysis comparing studies with surgical to non-surgical interventions for the management of ocular, eyelid, eyelash, and/or eyebrow burns in the acute phase of treatment.
Patients having surgery were found to have greater visual acuity on follow-up, shorter epithelial defect diameters on follow-up, greater changes in epithelial diameters from baseline, smaller epithelial defect areas on follow-up, greater changes in epithelial defect areas from baseline, greater numbers of healed epithelial defects, more keratitis infections, and a greater reduction in limbal ischemia, possibility preventing the need of a future limbal stem cell transplantation. Vision loss was higher in the surgical intervention group; however, vision loss on initial evaluation and more severe burns were present in this group.
Our results from analyses displayed in Additional file 2: Figure S1 demonstrate the distribution of available data for acute surgical and non-surgical outcomes related to ocular burns. Our findings revealed no differences between thermal, acid, alkali, and uncategorized chemical burns. The majority of included patients suffered from alkali burns. There were no differences in pain scores; however, Tamhane et al. found significantly greater reductions in discomfort scores day 1 with moderate burns and day 14 with severe burns following AMT compared to their control group. Surgical interventions were associated with reducing pain during the acute phase [16]. Vision loss was higher in the surgical group and not included in our report due to the unequal groups of higher severities of burns and vision loss prior to management. We believed these results incorrectly influenced the interpretation of data [2,15]. No differences were seen with time to management, changes in visual acuity, corneal haze, Schirmer and TBUT tests, time to epithelialization, corneal ulceration, symblepharon, and corneal vascularization. Initial surgical management is a reasonable option for Dua's Grade II to VI ocular burns. Surgery has a higher risk of ocular infections. This risk may be outweighed by the benefit of greater visual acuity at long-term follow-up and reduced defect sizes.
Limitations existed with our study findings. Studies that included surgical and non-surgical interventions were a mix of RCTs and retrospectively performed studies, primarily performed in India. Combining RCTs, the prospective cohort, and retrospective cohorts were performed in compliance with methods outlined by the Cochrane Collaboration to include all relevant data from the literature. There results provide little evidence for effect size estimate differences between observational studies and RCTs, regardless of specific observational study design, heterogeneity, inclusion of pharmacological studies, or use of propensity score adjustment [22]. We included patients with a mean age ≥ 15 years to account for studies that reported only means. This age cutoff was chosen on the basis of varying definitions for adult patients from starting ages 15 to 21 within the literature and to maintain a comprehensive review [23]. Only eight studies were available for comparison, limiting the ability to use funnel plots for assessing study heterogeneity. Therefore, sensitivity analysis was best performed using single study elimination to identify which study contributed the most heterogeneity. Sensitivity analysis was not mentioned for all outcomes if the initial results were not significant, and the analysis did not significantly contribute to a change in statistical significance. Studies were inconsistent with reporting the involvement of anatomical subunits surrounding the eye following ocular burns and the eye itself following eyelid burns. Criteria for determining grades of corneal injury varied between Roper-Hall and Dua's classifications. Experts often have different opinions on grade severity within the same classification for corneal injury. Many tests including limbal ischemia are subjective and depend on clinical interpretation. Corneal clarity and corneal haze were inconsistently used. We attempted to unify the data by converting corneal clarity to corneal haze. Although the majorities of studies were performed in India and had a higher proportion of male participants, the highest level of care was provided to all study participants. As long as medical facilities are equipped with standard resources, the results may be generalizable to other populations. Study dates ranged from 1983 through 2017, a 34-year time period with many gaps throughout the timeline. Our search revealed a lack of data reported within the literature. Outcomes and complications with no identifiable information included scald burns, contact burns, electrical burns, superficial burns, number of days on a ventilator, ICU LOS, need for reconstruction, time to reconstruction, mortality, keloid/hypertrophic scars, and compression of a neurovascular bundle. Outcomes and complications were unavailable for meta-analysis due to single reports were %TBSA, Dua's grade I burns, Dua's grade VI burns, limbial ischemia on follow-up, limbal ischemia changes from baseline, hospital LOS, intubation rate, inhalation injury, eyelid contracture, and entropian on follow-up. Only one study reported the cultured organism following keratitis. This may result in the inability of the surgeon to determine the best management during the acute phase for the best outcomes in the chronic phase of reconstruction. The small sample volume for comparison may explain the high risks of selection bias and unclear bias, and large degrees of heterogeneity observed across studies following metaanalysis. We used the random effects model in all outcomes to reduce the risk of bias in individual studies and across studies. To maintain the highest level of consistency and minimize heterogeneity, the authors applied this method for all results. Many studies could not be included due to no comparative groups or single cases. Sample demographics lacked comorbidities, limiting the ability to assess the influence of confounding patient variables on outcomes and complications.
These limitations demonstrate why it was important to perform this systematic review and meta-analysis. By conducting this never performed systematic review and meta-analysis, we identified future areas of research that can contribute a wealth of knowledge to the literature for healthcare providers and patients. In addition, we compared the differences in outcomes and complications across studies with the highest level of evidence available.

Conclusion
Patients having surgery for ocular, eyelid, and/or eyelash burns were found to have greater visual acuity on follow-up, shorter epithelial defect diameters on follow-up, greater changes in epithelial diameters from baseline, smaller epithelial defect areas on follow-up, greater changes in epithelial defect areas from baseline, greater numbers of healed epithelial defects, more keratitis infections, and a greater reduction in limbal ischemia, possibility preventing the need of a future limbal stem cell transplantation.