Advance articles

Looking for tumor-specific biomarkers is particularly important for Hepatocellular carcinoma diagnosis and treatment. In this study, we firstly reported the gene OCIAD2 could inhibit tumor growth and metastasis in HCC. OCIAD2 may contribute to HCC treatment development.

We investigated breast carcinogenesis in rodent models of heritable fitness in the absence of induced physical activity and observed that cancer incidence is significantly lower in rats with high inherent aerobic capacity.

Increased personal exposure to PM_2.5 and BaP from household coal combustion may be related to decreased leukocyte mitochondrial DNA copy number, a marker of oxidative stress, in non-smoking women residing in rural China.

In this work, we have studied the biology behind DLBCL central nervous system (CNS) tropism and potential biomarkers for CNS relapse prediction. We show that ITGA10, PTEN, CD44, cadherin-11 and lactoferrin levels are altered in CNS lymphomas.

Curcumin sensitized chemoresistant pancreatic cancer cells to gemcitabine and prevented the formation of spheroids, a hallmark of CSCs, by inhibiting the expression of the PRC2 subunit EZH2 and its related lncRNA PVT1.

We found that triple-negative breast cancer patients who developed metastasis had significantly higher level of intratumor heterogeneity (ITH). Also, higher ITH was significantly associated with the development of metastasis and was predictive of significantly worse metastasis-free survival.

We analyzed by NGS a Li–Fraumeni syndrome family with a 4-year-proband presented a TP53 deletion inherited from his mother. Whole-exome sequencing uncovered 25 predicted deleterious variants inherited from the father that potentially worsen the already altered genetic background in the proband.

In addition to its role in homologous recombination, Dicer also participates in DNA double-strand break (DSB) repair by facilitating non-homologous end joining. Moreover, the expression level of Dicer is correlated with chemoresistance in colon cancer patients.

The methylation of subtelomeric repeat D4Z4 and pericentromeric repeat NBL2 in peripheral blood leukocytes was examined with pyrosequencing in prostate cancer. The methylation of D4Z4 was associated with BCR.

We present relevant epidemiological data on the association between alcohol consumption and oesophageal cancer risk, including the effect modification by genetic polymorphisms, potential biological mechanisms and emerging areas of research that could lead to new and effective preventive interventions.

PSIP1/p75/LEDGF promotes the expression of key cell-cycle genes by facilitating the association of RNA pol II to their promoters. PSIP1 over-expresses in TNBC patients and patient-derived cell lines, and its silencing significantly decreases the migration, invasion and tumorigenicity of TNBC cells.

This study identified a panel of epigenetic liquid biopsy markers closely associated with overall immunologic conditions. This is the first report that revealed the correlation between DNA methylation in peripheral blood leukocyte and platelet parameters.

MMPs play an important role in tumor progression and metastasis, including ECM degradation, modification of the cell–cell and cell–ECM interactions, invasion, migration and angiogenesis. This review critically assesses the role of MMPs in relation to cancer growth and future prospects.

Use of dark hair dye shades was associated with 51% increased breast cancer risk among African Americans (AAs) and Whites and 72% increased ER+ disease risk among AAs, while chemical relaxer use was associated with 74% increased risk among Whites.

Prostate cancer cells rely heavily on cholesterol. In prospective cohort studies, we assessed the transcriptome of intratumoral cholesterol regulators. Cancers that ultimately became lethal were characterized by de novo cholesterol synthesis rather than transcellular uptake or esterification of cholesterol.

In this large study among participants of screening colonoscopy, Fusobacterium was significantly associated with colorectal cancer diagnosis and stage, but not with adenomas. Our observations support the hypothesis that Fusobacterium multiplies in the conditions caused by the malignant tumor.

We found a significant association between the entire mTOR pathway and breast cancer risk, particularly with overall and ER− breast cancer risk in women of African ancestry, driven primarily by two different genes, PRKAG3 and RPS6KA3, respectively.

Molecules that substantially alter important signaling pathways are expected to help treat ovarian cancer. Based on in vitro and in vivo experimental studies, we described a number of functional contributions of melatonin controlling cellular and molecular signals associated with this malignancy.

Time caloric restriction avoided the neoplastic transformation in a Diethylnitrosamine protocol, which induced cirrhosis followed of hepatocellular cancer in rats.

Intra-tumor heterogeneity (ITH) measured by MATH independently predicted survival in male CRC patients. Additionally, the association between MATH and related genomic aberration was different based on gender. We further provided potential mechanisms of ITH on RNA and DNA level.

We show that sulforaphane, a diet-derived cancer prevention agent, reduces PRMPT5/MEP50 function to reduce cancer cell survival.

The findings of this report support the inclusion of infection with Opisthorchis felineus among the Group 1 biological carcinogens. Oxysterol-like metabolites of liver fluke origin and the occurrence of biliary intraepithelial neoplasia (BilIN) in liver fluke-infected hamsters support this interpretation.