Inhibitory effect of topical application of polymerized ferulic acid, a synthetic lignin, on tumor promotion in mouse skin two-stage tumorigenesis

Asanoma, Masaharu; Takahashi, Kazuhiko; Miyabe, Masaki; Yamamoto, Katsuhiko; Yoshimi, Naoki; Mori, Hideki; Kawazoe, Yutaka

doi:10.1093/carcin/15.9.2069

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Inhibitory effect of topical application of polymerized ferulic acid, a synthetic lignin, on tumor promotion in mouse skin two-stage tumorigenesis

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Abstract

A dehydrogenation polymer of ferulic acid (DHP-FA), a synthetic lignin, was evaluated for its ability to inhibit tumor promotion by 12-O-tetradecanoylphorbol-13-acetate (TPA) in the 7,12-dimethylbenz[a]anthracene-treated skin of female ICR mice. Topical application of DHP-FA inhibits TPA-induced tumor promotion, whereas a monomeric ferulic acid does not show the inhibitory effect.

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Inhibitory effect of topical application of polymerized ferulic acid, a synthetic lignin, on tumor promotion in mouse skin two-stage tumorigenesis

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Inhibitory effect of topical application of polymerized ferulic acid, a synthetic lignin, on tumor promotion in mouse skin two-stage tumorigenesis

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