Liver cancer genome sequencing revealed target pathways for liver cancer prevention/therapy and the reason for genomic instability in liver cancer.
Cancer Biomarkers and Molecular Epidemiology
Short leukocyte telomere length, alone and in combination with smoking, contributes to increased risk of gastric cancer or esophageal squamous cell carcinoma
We describe an association between short telomere length in leukocytes with elevated risk of gastric cancer or esophageal squamous cell carcinoma. Short telomere length might be a potential molecular marker, in combination with lifestyle risk factors, to identify high-risk individuals.
Up-regulation of mismatch repair genes MSH6, PMS2 and MLH1 parallels development of genetic instability and is linked to tumor aggressiveness and early PSA recurrence in prostate cancer
Overexpression of the mismatch repair genes MSH6, MLH1 and PMS2 was analyzed in a tissue microarray containing more than 11 000 prostate cancer samples. Results indicate that overexpression is common in prostate cancer and linked to ETS-related gene fusion development, increased genetic instability and aggressive cancer phenotype.
Polymorphisms in microRNA binding sites of mucin genes as predictors of clinical outcome in colorectal cancer patients
In our study, we describe for the first time that genetic variation within microRNA target sites of mucin genes are significantly associated with colorectal cancer risk and patient’s survival.
Inflammation, Microenvironment and Prevention
Role of p53 in silibinin-mediated inhibition of ultraviolet B radiation-induced DNA damage, inflammation and skin carcinogenesis
p53 plays an important role in silibinin-mediated inhibition of UVB-induced skin carcinogenesis and associated inflammatory response in SKH-1 hairless mouse. Silibinin-mediated repair of UVB-induced DNA damage is only partially dependent on p53.
Anti-inflammatory natural product goniothalamin reduces colitis-associated and sporadic colorectal tumorigenesis
Goniothalamin (GTN), a naturally occurring styryl lactone, effectively inhibited colitis, colitis-associated cancer and spontaneous colon cancer in mice, through its potent anti-inflammatory activity.
We showed that YAP/TAZ contribute to non-small cell lung cancer cells proliferation by regulating the expression of MCM7 gene and its hosted microRNAs (miR-25, 93 and 106b). These latters contribute to lower p21 expression in tumor compared to normal tissue.
Cancer-associated fibroblasts regulate keratinocyte cell–cell adhesion via TGF-β-dependent pathways in genotype-specific oral cancer
We show that disruption of cancer cell adhesion and promotion of invasion by fibroblasts is dependent on TGF-β in genotype-specific oral cancer. The findings may lead to new therapeutic opportunities for the control of this most aggressive type of cancer.
Loss of free fatty acid receptor 2 enhances colonic adenoma development and reduces the chemopreventive effects of black raspberries in ApcMin/+ mice
Our study demonstrates that FFAR2 is a tumor suppressor in colon carcinogenesis and that BRBs need functional FFAR2 to be chemopreventive. BRBs modulate GR-1+ neutrophils and IL-1β expression in colon in a FFAR2-dependent manner, thereby enhancing the antitumor immune microenvironment.
Eukaryotic translation initiation factor 5A2 promotes metabolic reprogramming in hepatocellular carcinoma cells
Oncogene eukaryotic translation initiation factor 5A2 (EIF5A2) plays a critical role in the malignant progression of many solid tumors. Here, we showed that EIF5A2 could promote cell proliferation and trigger cellular metabolic reprogramming including glucose metabolism and fatty acid biosynthesis in liver cancer cells.