The awards, sponsored by Oxford University Press, are presented at the biannual meetings of the European Association for Cancer Research (EACR). The Anthony Dipple Carcinogenesis Award is for major contributions to research in the field of carcinogenesis, and the Carcinogenesis Young Investigator Award is for a recent, significant contribution to carcinogenesis research by an investigator under the age of 40.
Anthony Dipple Carcinogenesis Award
The winner of this senior award for major contributions to research in the field of carcinogenesis is Michael Karin (University of California, San Diego, USA).
Dr. Karin has spent his entire academic career investigating stress and inflammation signaling covering the entire gamut of research approaches from basic biochemistry through molecular cell biology to animal pathophysiology. After discovering how environmental stress caused by either infection, inflammation or exposure to toxic substances leads to activation of AP-1, NF-κB and other transcription factors, his lab began to examine the role of the key signaling pathways controlling these transcription factors in the pathogenesis of cancer, degenerative and metabolic diseases.
The Karin group has identified some of the fundamental mechanisms through which inflammation and obesity promote tumor development and progression and contribute to type II diabetes. They had established the mechanisms through which members of the IL-6 cytokine family contribute to the development of colorectal and liver cancer through activation of STAT3 and other transcription factors. They had also established the complex and cell type specific mechanisms through which NF-κB activation via IκB kinases (IKK) controls development and progression of colon, liver and prostate cancers. They were amongst the first to demonstrate that not only innate immune cells, such as macrophages, but also adaptive immune cells, including T regulatory cells and B lymphocytes, also contribute to tumorigenesis and its progression. Through this work, Dr. Karin has contributed to the founding of the Inflammation and Cancer field.
Read the latest article from Dr. Karin free online:
Liver carcinogenesis: from naughty chemicals to soothing fat and the surprising role of NRF2
View Dr. Karin's presentation for the Anthony Dipple award here.
Read articles by previous winners of the Anthony Dipple Award:
- David Lane, UK (2004)
p53 from pathway to therapy
- Raymond N. Dubois, USA (2006)
Cancer prevention: strategy for the future
- Robert A Weinberg, USA (2008)
Mechanisms of malignant progression
- David Livingston, USA (2010)
BRCA1 and BRCA2: breast/ovarian cancer susceptibility gene products and participants in DNA double-strand break repair
- Carlo Croce, USA (2012)
microRNA involvement in human cancer
- Varda Rotter (2014)
The paradigm of mutant p53-expressing cancer stem cells and drug resistance
Carcinogenesis Young Investigator Award
This award recognises a recent, significant contribution to carcinogenesis research by an investigator under the age of 40 on 1 July 2015. The winner is Dr. Ludmil Alexandrov (Los Alamos National Laboratory, Los Alamos, USA).
Ludmil Alexandrov is an Oppenheimer Fellow in the Theoretical Biology and Biophysics Group and the Center for Nonlinear Studies at Los Alamos National Laboratory. He earned his Bachelor of Science degree in Computer Science from Neumont University and received his Master’s of Philosophy in Computational Biology as well as his Ph.D. in Cancer Genetics from the University of Cambridge.
During his PhD training, Ludmil developed the first mathematical model describing signatures of mutational processes in human cancer as well as the first computational framework for extracting these signatures from next-generation sequencing data from cancer genomes. Ludmil subsequently used this framework to map the mutational signatures in 7,042 cancer genomes providing the first comprehensive map of the mutational signatures in human cancer. More recently, Ludmil mapped the signatures of clock-like mutational processes operative in normal somatic cells and demonstrated that mutational signatures can be used for targeted cancer therapy.
Read the latest article from Dr. Alexandrov free online:
Understanding mutagenesis through delineation of mutational signatures in human cancer
View Dr. Alexandrov's presentation for the Young Investigator award here.
Read articles by previous winners of the Young Investigator Award:
- Maria Blasco, Spain (2004)
Effectors of mammalian telomere dysfunction: a comparative transcriptome analysis using mouse models
- Manel Esteller, Spain (2006)
The necessity of a human epigenome project
- Victor Velculescu, USA (2008)
Defining the blueprint of the cancer genome
- Thomas Helleday, UK (2010)
Homologous recombination in cancer development, treatment and development of drug resistance
- Lars Zender, Germany (2012)
Immune surveillance of senescent cells—biological significance in cancer- and non-cancer pathologies
- Lin He (2014)
An expanding universe of the non-coding genome in cancer biology