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Pathways for salvage and protection of the heart under stress: novel routes for cardiac rejuvenation

Cannata, Antonio, Cardiovasc Res (2016) 111(2) doi: 10.1093/cvr/cvw106 - Click here to view the abstract

Schematic representation of the mechanism involved in cardiac aging. Cardiac aging is characterized by several structural and functional changes. Excess of nutrients, increased oxidative stress reduction in age-regulating hormones, may contribute to progressive accumulation of dysfunctional mitochondria and reduced protein turnover and changes in ECM, characterized by increased deposition of collagen and phenotypical changes of fibroblasts into myofibroblasts.

Pathways for salvage and protection of the heart under stress: novel routes for cardiac rejuvenation

Cannata, Antonio, Cardiovasc Res (2016) 111(2) doi: 10.1093/cvr/cvw106 - Click here to view the abstract


Schematic representation of the putative pathways to rejuvenate the aged myocardium. Therapeutic approaches that interfere with the molecular pathways that are involved in cardiac aging have the potential to delay or reverse the onset of chronic cardiovascular conditions and reverse cardiac dysfunction.

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