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in Cardiovascular Research > Proteomics couples electrical remodelling to inflammation in a murine model of heart failure with sinus node dysfunction

Published: 25 April 2024

Graphical Abstract Graphical Abstract

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Physiological measurements, experimental workflow, and proteome and phospho...

in Cardiovascular Research > Proteomics couples electrical remodelling to inflammation in a murine model of heart failure with sinus node dysfunction

Published: 25 April 2024

Figure 1 Physiological measurements, experimental workflow, and proteome and phosphoproteome measurements. ( A ) Physiological measurements from CTRL and HF mice. Left: ejection fraction (EF; **** P < 0.0001, Mann–Whitney U test); middle: heart weight/tibia length (HW/TL; **** P < 0.0001, Mann–Whit

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Linking local inflammation and macrophage expansion with SND in HF. (A...

in Cardiovascular Research > Proteomics couples electrical remodelling to inflammation in a murine model of heart failure with sinus node dysfunction

Published: 25 April 2024

Figure 4 Linking local inflammation and macrophage expansion with SND in HF. ( A ) Sinus node proteome measurements from human subjects with HF as the cause of death ( n = 4) and human subjects without HF ( n = 3). Left, volcano plot shows log 2 transformed fold change of sinus node protein abundance in t

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Linking local inflammation to electrical remodelling. (A, left) Re...

in Cardiovascular Research > Proteomics couples electrical remodelling to inflammation in a murine model of heart failure with sinus node dysfunction

Published: 25 April 2024

Figure 5 Linking local inflammation to electrical remodelling. ( A , left) Representative Galectin-3 western blot of sinus node biopsies SAN explants incubated in the absence (control) or presence (LPS) of 1 μg/mL LPS. Corresponding stain-free total protein gel used for quantification is shown in the lower p

Journal Article

Proteomics couples electrical remodelling to inflammation in a murine model of heart failure with sinus node dysfunction

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Konstantin Kahnert and others

Cardiovascular Research, cvae054, https://doi.org/10.1093/cvr/cvae054

Published: 25 April 2024

Supplementary data

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Sinus node ion channel protein expression is reduced and recapitulates redu...

in Cardiovascular Research > Proteomics couples electrical remodelling to inflammation in a murine model of heart failure with sinus node dysfunction

Published: 25 April 2024

Figure 2 Sinus node ion channel protein expression is reduced and recapitulates reduced heart rate. ( A ) Differential protein expression analysis. Volcano plot shows log 2 transformed fold change of protein abundances in HF compared to CTRL on the x -axis and −log 10 ( t -test P -value) on the y -axis.

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Pharmacovigilance analysis and multi-omics data integration highlights prot...

in Cardiovascular Research > Proteomics couples electrical remodelling to inflammation in a murine model of heart failure with sinus node dysfunction

Published: 25 April 2024

Figure 3 Pharmacovigilance analysis and multi-omics data integration highlights proteins linked to bradycardic phenotype in humans. ( A ) Proteins significantly differentially expressed in the mouse HF with SND model which are also significantly associated with heart rate based on a resting heart rate GWAS o

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Targeting galectin-3 signalling prevents SND in HF. (A) Experiment...

in Cardiovascular Research > Proteomics couples electrical remodelling to inflammation in a murine model of heart failure with sinus node dysfunction

Published: 25 April 2024

Figure 6 Targeting galectin-3 signalling prevents SND in HF. ( A ) Experimental design for evaluating prevention of SND in TAC-induced HF by systemic galectin-3 targeting with MCP. ( B ) Effect of MCP treatment on the change in heart rate in vivo in HF. Left, mean ± S.E.M. (as well as individual data point

Journal Article

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