Pityriasis rubra pilaris (PRP) is a rare papulosquamous disorder. While PRP has been reported following various vaccinations, its association with the Shingrix vaccine has not been documented. Here, we present the first two reported cases of PRP following Shingrix vaccination.

This ethical dilemma examines a case in which a 16-year-old patient, deemed Gillick competent, wishes to start isotretinoin for severe acne despite her parents’ objections. The conflict highlights the tension between respecting a minor’s informed autonomy and parental authority in medical decision-making. The discussion focuses on balancing beneficence, non-maleficence, and autonomy, offering strategies for clinicians to navigate such complex scenarios.

We present an unusual case of ulceration associated with diffuse dermal angiomatosis of the abdomen. Dermatologists should be aware of the use of topical glyceryl trinitrate spray to successfully resolve the ulceration associated with diffuse dermal angiomatosis, particularly where surgical intervention may be unsuitable.

This population-based study assessed the relationship between low vitamin D levels and alopecia subtypes in over 52,000 patients from the All of Us NIH database. Results indicated no significant difference in vitamin D levels between scarring and non-scarring alopecia, though younger age, Black and Asian race, and male gender were associated with lower vitamin D levels.

Anti-Ki/SL antibodies are most commonly found in systemic lupus erythematosus patients, they show broader relevance to systemic sclerosis and dermatomyositis. We developed in-house ELISA for anti-Ki/SL antibodies which are not included in lineblot.

The Harmonizing Outcomes Measurement in Eczema (HOME) initiative developed a core outcome set for atopic dermatitis (AD), but uptake in trials is still limited. An online survey was sent out to corresponding authors of AD interventional randomized clinical trials, to assess their awareness to the HOME COS, evaluate barriers to uptake, and identify facilitators to enhance implementation. Survey respondents emphasized increasing awareness of the COS in the research community, reducing the burden associated with using the COS, and ensuring applicability to diverse populations.

Hidradenitis suppurativa is known to be associated with a psychological burden on patients. Additionally, weight management and habit modification are often part of a multifaceted approach to care in patients with hidradenitis suppurativa. Given that information, this letter explores the relationship between hidradenitis suppurativa and eating disorders to better understand the relationship between hidradenitis suppurativa, lifestyle modifications, body image, and psychiatric comorbidities.

There are currently no guidelines on the management of severely dysplastic naevi (SDN) in the UK or internationally. There is generally consensus for re-excision of SDN with positive margins, however there is variation in clinical practice of completely excised SDN. We carried out a retrospective observational study reviewing the management of severely dysplastic naevi across two NHS Trusts over a 5 year period. Our results demonstrate a considerable variation in practice between two trusts and potential overtreatment of completely excised SDN. This therefore highlights the need for consensus evidence-based guidelines to standardise care for patients with SDN.

Here we report a case of giant bullous pilomatrixoma arising on the left supraclavicular fossa of a sixteen-year-old girl. This presented as an asymptomatic 6.5cm x 4cm pink-red, non-pulsatile raised bulla with a bizarre, irregular and well-demarcated outline. Histology showed an admixture of cell types consisting of monotonous basophilic epithelial cells, and collections of ghost cells lacking viable nuclei, with a surrounding giant cell reaction consistent with a pilomatrixoma.

Despite its limitations, our pilot study presents the first proof of principle that topical T3 can indeed promote hair growth (i.e., prolong anagen) and can stimulate the intrafollicular production of a potent hair growth factor (FGF7/KGF) in intact human scalp skin ex vivo, i.e. directly in the human target organ. We also show that the simple, clinically relevant vehicle we have developed and tested here facilitates topical HF-targeting THs delivery through an intact epidermal barrier.