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Original Article
Grade 3 and Grade 4 Cutaneous toxicities in patients across multiple solid tumour types receiving checkpoint inhibitor therapy: An observational study. The experience of a single large specialist institution
Zaina Sharif and others
Clinical and Experimental Dermatology, llaf173, https://doi.org/10.1093/ced/llaf173
Skin toxicity is the most commonly reported adverse event secondary to immune checkpoint inhibitors for cancer treatment. It can vary in severity from grade 1 (mild) to grade 4 (life-threatening) and can result in discontinuation of valuable immunotherapy. This study determines the incidence of grade 3 and 4 skin toxicity secondary to multiple regimens of immune checkpoint inhibitors for multiple solid tumour types at a single tertiary oncology institution and explores the cutaneous presentation of severe skin toxicity, real world management, rates of discontinuation of immune checkpoint inhibitors and survival outcomes amongst this population.
Original Article
A Long-Term Real-Life Safety Study of Guselkumab in Psoriasis Patients with Infectious Comorbidities, Malignancies or Heart Disease: The EARLY Study
Edoardo Mortato and others
Clinical and Experimental Dermatology, llaf172, https://doi.org/10.1093/ced/llaf172
This real-life study evaluated the safety of guselkumab in 1,024 patients with moderate-to-severe psoriasis who also had chronic infections, cancer, or heart disease. No viral reactivation occurred in patients with infections, and guselkumab was found to be safe for patients with cancer or heart disease. The findings provide valuable insights for managing psoriasis treatment in patients with these comorbidities.
Original Article
Risk of Nonmelanoma Skin Cancers and Cutaneous Melanoma after Psoralen and Ultraviolet A Therapy in Psoriasis Patients: A Nationwide Taiwanese Cohort Study
Mei-Ju Ko and others
Clinical and Experimental Dermatology, llaf169, https://doi.org/10.1093/ced/llaf169
In this nationwide cohort study conducted in Taiwan, we evaluated 13,245 psoriatic patients with a maximum follow-up of 18.0 years. Our findings suggest that PUVA therapy was associated with an increased risk of nonmelanoma skin cancer but not melanoma in Asian psoriatic patients with Fitzpatrick skin phototypes II to V.
Original Article
Long-term cardiovascular outcomes among adult survivors of Stevens–Johnson syndrome and toxic epidermal necrolysis: a retrospective cohort study using TriNetX
Sheng-Hsiang Ma and others
Clinical and Experimental Dermatology, llaf046, https://doi.org/10.1093/ced/llaf046
Few studies have evaluated the long-term sequelae of Stevens–Johnson syndrome and toxic epidermal necrolysis. In this retrospective cohort study, we found that these patients had a significantly elevated risk of major cardiovascular event, ischaemic heart disease, cerebrovascular disease and mortality compared with healthy controls.
Original Article
Trends in Cutaneous Malignant Melanoma Mortality in Europe from 1992 to 2021
Mercedes Sendín-Martín and others
Clinical and Experimental Dermatology, llaf170, https://doi.org/10.1093/ced/llaf170
This study analyzes melanoma mortality trends across 28 European countries from 1992 to 2021, revealing significant variations by age, gender, and geography. While patients over 75 have been responsible for the increase in mortality until 2015, younger patients have shown a decline since the 1990s. The findings highlight the need for ongoing monitoring, particularly in Central and Eastern Europe and among men in Northern Europe, where recent increases in mortality rates have been observed.
Cpd - Genetic Report
Homozygous JUP variant in Naxos disease: a case report of cardiac and dermatologic involvement
Marina de la Puente Alonso and others
Clinical and Experimental Dermatology, llaf174, https://doi.org/10.1093/ced/llaf174
We present the case of a 62-year-old man diagnosed with ARVD at 42, who exhibited severe right ventricular involvement requiring an implantable cardioverter-defibrillator. Genetic analysis identified a homozygous JUP variant (c.468G>A), previously reported as pathogenic but never in the homozygous state, expanding the disease's phenotypic spectrum and highlighting the importance of genetic screening and long-term follow-up.
Letter to the Editor
How the use of sonidegib beyond clinical complete response impacts tolerability in locally advanced basal cell carcinoma: A retrospective monocentric analysis
Alessia Villani and others
Clinical and Experimental Dermatology, llaf171, https://doi.org/10.1093/ced/llaf171
Sonidegib is an orally administered Hedgehog inhibitor, approved for use in adult patients with locally advanced basal cell carcinoma who are not candidates for curative surgery or radiation therapy. It is well known that longer sonidegib intake may be related to adverse events which may have a deep impact on patients’ quality of life. More data are required to further investigate possible strategies to adopt to increase patients’compliance to treatment, reducing the risk of adverse events and increasing treatment outcomes. The aim of our study was to investigate the effect on tolerability of using sonidegib beyond clinical complete response in locally advanced basal cell carcinoma patients who had previously achieved clinical Complete Remission with sonidegib.
Letter to the Editor
BRodalumab effectiveness in psoriatic patients that experienced anti-IL17 Intra-Class failure: a multicentre, retrospective study (BRIC - Study) IL-PSO (Italian Landscape Psoriasis)
Diego Orsini and others
Clinical and Experimental Dermatology, llaf168, https://doi.org/10.1093/ced/llaf168
The aim of this retrospective study is to assess the efficacy of brodalumab in a multicenter Italian cohort of psoriasis patients, who had not achieved Psoriasis Area Severity Index (PASI) 75 or had lost response to any of the other IL-17 blockers (Bimekizumab, Ixekizumab, Secukinumab).
CPD - Clinicopathological Case
A white papule on the leg
Gianluca Avallone and others
Clinical and Experimental Dermatology, llaf164, https://doi.org/10.1093/ced/llaf164
A 52-year-old male patient presented with a progressively enlarging, asymptomatic white papule on his right leg. Histopathological examination revealed fascicles of collagen separated by dense, diffuse deposits of mucin intermixed with numerous fibrocytes, and a few spindle-shaped fibroblasts with some vacuolization.
Specialty Certificate Examination Case
General dermatology and dermatology in primary health care
Fiona Sexton and others
Clinical and Experimental Dermatology, llaf165, https://doi.org/10.1093/ced/llaf165
Nail findings in Darier's disease can often be confused with other nail pathologies. This Speciality Certificate Examination question aims to clarify the common nail findings which may be present on exam in Darier's disease.
Impact Factor
3.7
5 year Impact Factor
3.4
Dermatology
18 out of 94
Highly Cited

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