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Volume 26, Issue 12
1 December 2016
ISSN 1047-3211
EISSN 1460-2199
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Tags: neurons
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    Cover Image

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    Cover Picture: Interrogating inhibitory plasticity in epileptic circuits using physiology and computational modeling: Confocal image of a pair of synaptically connected dentate basket cells filled with biocytin (red) during recording. The section shows immunostaining for parvalbumin (green) and somato-dendritic co-labeling for biocytin and parvalbumin (yellow) in the recorded pair. Schematic of a recording electrode (white) and spontaneous inhibitory synaptic current recordings (blue) are illustrated (lower panels). A pair of simulated basket cells (in white) with action potential firing in the presynaptic neuron and current response in the postsynaptic model neuron is illustrated (upper right). Using complementary physiological and computational techniques Yu et al. identify cell-type specific alterations in inhibitory inputs to basket cell in experimental epilepsy and examine their impact on network rhythms. See Yu et al. Functional reduction in cannabinoid-sensitive heterotypic inhibition of dentate basket cells in epilepsy: impact on network rhythms. See Yu et al. 2016. Functional reduction in cannabinoid-sensitive heterotypic inhibition of dentate basket cells in epilepsy: impact on network rhythms. Cereb Cortex 26(11): 4299-4314, 2016.

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