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Jiao Jiao, Kei Murakami, Kenichiro Itami, Palladium-catalyzed C–H Arylation of Pyridines with Aryl Triflates, Chemistry Letters, Volume 45, Issue 5, May 2016, Pages 529–531, https://doi.org/10.1246/cl.160133
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Abstract
Methods that can directly arylate pyridines have significant potential in synthetic chemistry. Herein, we present palladium-catalyzed C–H arylation of pyridines with aryl triflates that occurs regioselectively at the C3 positions of the pyridine core. A variety of aryl triflates and pyridines were applicable to the reaction to provide C3-arylated pyridines regardless of sterics or electronics of the pyridine cores.
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